Endogenous activated angiotensin-(1-7) plays a protective effect against atherosclerotic plaques unstability in high fat diet fed ApoE knockout mice

International Journal of Cardiology
Jianmin YangCheng Zhang

Abstract

We recently found that exogenous angiotensin-(1-7) [Ang-(1-7)] inhibits Angiotensin II (Ang-II)-induced atherosclerotic lesion formation and enhances plaque stability. Our objective was to evaluate the role of endogenous activated Ang-(1-7) during atherosclerosis. In mice, the effects of endogenous Ang-(1-7) on atherogenesis in early stage and plaque stability in late stage were observed in ApoE knockout (ApoE-/-) mice fed with a high fat diet. Blockage of endogenous Ang-(1-7) with A779, an Ang-(1-7) antagonist, did not increase early plaque lesion formation, however, it remarkably enhanced contents of lipids and macrophages and decreased contents of vascular smooth muscle cells (VSMCs) and collagens in late lesions. The expressions of proinflammatory cytokines, and the expressions and activities of matrix metalloproteinases were significantly elevated in A779-treated group than those in vehicle-treated group in late lesions. Exogenous Ang-(1-7) treatment attenuated early atherosclerotic plaque formation and enhanced late plaques stability in this model. The contents of Ang-II and Ang-(1-7) and activity of ACE2 in late atherosclerotic plaques were higher than those of early atherosclerotic lesions. Endogenous activated Ang-(1-7...Continue Reading

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Citations

Jul 28, 2015·Trends in Cardiovascular Medicine·Xiao Yu TianWing Tak Wong
Oct 10, 2018·American Journal of Physiology. Endocrinology and Metabolism·Justin LoloiAmy C Arnold
May 5, 2018·Journal of Cardiovascular Development and Disease·Shutan Liao, Craig S McLachlan
Oct 6, 2020·Frontiers in Physiology·Gabriela M SilvaThyago M Queiroz
Mar 22, 2019·Nature Reviews. Cardiology·Laura CalvilloGianfranco Parati
Jul 20, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Wenjing LiJianmin Yang
Mar 12, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Bárbara Caroline Dias FariaAna Cristina Simões E Silva
Aug 22, 2021·Molecular Biology Reports·Fernanda Rocha Chaves MoreiraAna Cristina Simões E Silva

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