Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE

Journal of Neuroinflammation
Nilufer EsenPaula Dore-Duffy

Abstract

In the brain, chronic inflammatory activity may lead to compromised delivery of oxygen and glucose suggesting that therapeutic approaches aimed at restoring metabolic balance may be useful. In vivo exposure to chronic mild normobaric hypoxia (10 % oxygen) leads to a number of endogenous adaptations that includes vascular remodeling (angioplasticity). Angioplasticity promotes tissue survival. We have previously shown that induction of adaptive angioplasticity modulates the disease pattern in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE). In the present study, we define mechanisms by which adaptation to low oxygen functionally ameliorates the signs and symptoms of EAE and for the first time show that tissue hypoxia may fundamentally alter neurodegenerative disease. C57BL/6 mice were immunized with MOG, and some of them were kept in the hypoxia chambers (day 0) and exposed to 10 % oxygen for 3 weeks, while the others were kept at normoxic environment. Sham-immunized controls were included in both hypoxic and normoxic groups. Animals were sacrificed at pre-clinical and peak disease periods for tissue collection and analysis. Exposure to mild hypoxia decreased histological evidence...Continue Reading

References

Jan 1, 1993·Advances in Experimental Medicine and Biology·P Dore-DuffyL Dragovic
Sep 15, 1996·Journal of Neuroscience Research·B CannellaC S Raine
Mar 2, 1999·Microvascular Research·P Dore-DuffyJ C LaManna
Jan 1, 2003·The American Journal of Pathology·Stefanie GauppCedric S Raine
Feb 1, 2003·Journal of the Neurological Sciences·Hans Lassmann
Aug 10, 2004·The Journal of Experimental Biology·Joseph C LaMannaPaola Pichiule
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
May 26, 2005·Pharmacological Reviews·Brian T Hawkins, Thomas P Davis
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroshi NakamuraHirotoshi Tanaka
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy J McGeachyStephen M Anderton
Jan 20, 2006·Journal of Applied Physiology·Kui Xu, Joseph C Lamanna
Mar 23, 2006·Neurological Research·Yun-Hong DingJosé A Rafols
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ludmila V BagaevaBenjamin M Segal
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka KomiyamaYoichiro Iwakura
Jul 14, 2007·Antioxidants & Redox Signaling·Paula Dore-Duffy, Joseph C LaManna
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ramesh K Selvaraj, Terrence L Geiger
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Feb 24, 2009·Lancet Neurology·Bruce D Trapp, Peter K Stys
Aug 26, 2009·Nature Reviews. Immunology·Victor Nizet, Randall S Johnson
Oct 7, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Eugene D FestaDiego Cadavid
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn TrandemStanley Perlman
Mar 12, 2010·Neuroscience·N C BerchtoldC W Cotman
Apr 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Sean P Colgan, Cormac T Taylor
Apr 17, 2010·The British Journal of Dermatology·S SchremlP Babilas
Aug 12, 2010·PloS One·Johannes BrettschneiderHayrettin Tumani
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dongmei XingJohn W Harmon
Mar 5, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Samia RaghebRobert Lisak
Jun 15, 2011·Physiology·Jaume PadillaM Harold Laughlin
Jun 17, 2011·Expert Reviews in Molecular Medicine·Paula GrammasBradley Miller
Jun 28, 2011·The Tohoku Journal of Experimental Medicine·Qingping ZhengYongshan Hu
Sep 13, 2011·Current Opinion in Immunology·Burkhard Becher, Benjamin M Segal
Nov 10, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jamie C ZampellBabak J Mehrara

❮ Previous
Next ❯

Citations

Mar 8, 2017·Seminars in Cancer Biology·Veronica HuberLicia Rivoltini
Nov 24, 2017·F1000Research·Roshni A Desai, Kenneth J Smith
May 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sebok K Halder, Richard Milner
Jul 5, 2018·Frontiers in Neurology·Carlos R Camara-LemarroyV Wee Yong
Jul 10, 2019·Frontiers in Pharmacology·Kyle MaloneChristian Waeber
Dec 23, 2020·Brain : a Journal of Neurology·Sebok K Halder, Richard Milner
Jun 24, 2021·Mediators of Inflammation·Rodolfo Kölliker-FrersFrancisco Capani

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
X-ray
fluorescence-activated cell sorting
FACS

Software Mentioned

ImageJ
CTL
ImmunoSpot
CTL ImmunoSpot Analyzer

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here