Endogenous Adenosine May Be Related to Left Ventricular Dysfunction, Dilation, and Wall Thinning in Patients With Heart Disease

Circulation Journal : Official Journal of the Japanese Circulation Society
Yujiro KinomuraShinya Minatoguchi

Abstract

The role of endogenous adenosine in cardiac patients is still unclear, so we investigated the relationship between the plasma adenosine concentration and left ventricular (LV) function, LV dilation and LV wall thinning in cardiac patients.Methods and Results:In 97 cardiac patients, with angina pectoris, old myocardial infarction, dilated or hypertrophic cardiomyopathy, and valvular heart disease, plasma adenosine concentrations were measured using the LC-MS/MS system, and the LV function, LV end-diastolic dimension (LVDd), LV posterior wall thickness (LVPWth), and interventricular septum thickness (IVSth) were assessed by echocardiography. The plasma adenosine concentration was significantly higher in patients with a LV ejection fraction (EF), an indicator of the LV systolic function, <47% compared with those with LVEF ≥47% (P=0.027). There was no difference between the plasma adenosine concentration and E/e', an indicator of LV diastolic function. The plasma adenosine concentration was significantly higher in patients with LVDd ≥50 mm than in those with LVDd <50 mm (P=0.030). The plasma adenosine concentration was inversely correlated with IVSth (P=0.003) and LVPWth (P=0.0007). The plasma adenosine concentration was significan...Continue Reading

References

Dec 1, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shoji SanadaMasatsugu Hori
Nov 13, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroya MurakamiBunji Uno

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Citations

Apr 6, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi Asanuma, Masafumi Kitakaze
Jul 25, 2019·CNS Neuroscience & Therapeutics·Ying-Jiao LiuNai-Hong Chen
Jul 2, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Bunji Uno

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