Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning

Developmental Biology
J Capdevila, R L Johnson

Abstract

The gene noggin, originally cloned in Xenopus, encodes a secreted factor expressed in the Spemann organizer, where it functions to oppose the ventralizing influence of bone morphogenetic proteins (BMPs). Noggin protein acts by binding directly to BMPs, thereby preventing them from interacting with their receptors. Here we describe the pattern of expression of the chicken noggin gene during somite and limb development, two tissues in which BMPs have been postulated to play essential patterning roles. We find that noggin is expressed in dynamic restricted patterns consistent with an important role in the modulation of BMP signaling. Using a replication competent retrovirus we have ectopically expressed noggin in developing somitic and limb bud mesoderm and observed phenotypes consistent with complete block of BMP activity. This includes suppression of lateral somite differentiation and, in the limb, complete inhibition of chondrogenesis and local suppression of programmed cell death. In addition, we find that ectopic noggin expression in the limb has no effect on anteroposterior limb pattern, suggesting that BMPs are unlikely to play a significant role in this process. Taken together,, our results indicate that noggin is a key re...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M R UristA Lietze
Sep 1, 1994·Anatomy and Embryology·R HuangB Christ
Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
Oct 29, 1993·Science·T M LambR M Harland
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A T Dudley, E J Robertson
Apr 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S A Holley, E L Ferguson
Oct 10, 1997·Cell·R L Johnson, C J Tabin
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R D Dahn, J F Fallon
Sep 14, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hye-Won KangAlexei Bogdanov
May 5, 2005·Cytokine & Growth Factor Reviews·Noriyuki Tsumaki, Hideki Yoshikawa
Mar 8, 2000·Mechanisms of Development·T SchlangeT Brand
Apr 11, 2003·Nature·Stephen M WarrenMichael T Longaker
Aug 21, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hye-Won KangAlexei Bogdanov
Jul 31, 2007·Development, Growth & Differentiation·Benoît Robert
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J Capdevila, J C Izpisúa Belmonte
Feb 4, 2012·Journal of Dental Research·X HuY P Chen
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Nifuji, M Noda
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y YoshimuraK Takaoka
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M HockD Stanislaus
Dec 30, 2006·PLoS Genetics·Amitabha BandyopadhyayClifford J Tabin
Apr 9, 2009·PloS One·Neil Vargesson, Ed Laufer
Sep 10, 2008·Yi chuan = Hereditas·Guan Yang, Xiao Yang
Feb 23, 2000·The Journal of Cell Biology·A D WestonT M Underhill
Apr 28, 2006·Journal of Anatomy·Andrew A Pitsillides
Aug 15, 2001·Seminars in Arthritis and Rheumatism·C J Edwards, P H Francis-West
Jan 26, 2016·Seminars in Cell & Developmental Biology·Caroline J SheebaIsabel Palmeirim
Jul 27, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hairong PengJohnny Huard
Sep 24, 2004·Developmental Biology·Catherine ChesnuttLee Niswander
Jan 23, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cord E DohrmannBruce A Morgan
Sep 8, 2004·Journal of Cellular Biochemistry·Byeong S Yoon, Karen M Lyons
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wei LiuDorothy A Frenz
Jan 25, 2007·Annals of Plastic Surgery·Shushan JacobRichard E Kirschner
Sep 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kathryn L McCabeMarianne Bronner-Fraser
Nov 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Diane HuRalph S Marcucio
Aug 25, 2010·Korean journal of urology·Jeongyun JeongIsaac Yi Kim

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