Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons

Neuroscience
X F Zhou, R A Rush

Abstract

Neurotrophins are a family of proteins which act as survival and differentiative factors in the developing and mature nervous system. Extensive evidence has been provided for their retrograde action following incorporation into nerve terminals and transport to the cell body. In contrast, we now demonstrate that one neurotrophin, brain-derived neurotrophic factor, is transported anterogradely via both peripheral and central processes of spinal sensory neurons. Using newly generated antisera, we have examined the distribution of brain-derived neurotrophic factor immunoreactivity and found it to be present within a subpopulation of sensory somata, primarily those with a small-to-medium diameter. The immunoreactivity was accumulated on both the distal and proximal sides of a ligature on the sciatic nerve. The accumulation on the distal side, but not on the proximal side, was substantially reduced by pretreatment with brain-derived neurotrophic factor antibodies in vivo. In contrast to the periphery, the immunoreactivity only accumulated on the proximal side of a lesion of the dorsal root. In the spinal cord, most nerve terminals immunoreactive for brain-derived neurotrophic factor were identified in lamina II. Lesion of the dorsal ...Continue Reading

References

Oct 19, 1999·The Journal of Comparative Neurology·S L CochranE W Rubel
Sep 29, 2009·Neuroscience Bulletin·Ming-Gang Liu, Jun Chen
Feb 19, 2003·Brain Research. Brain Research Reviews·Sophie PezetS B McMahon
Feb 13, 2001·Trends in Neurosciences·D K BinderH E Scharfman
Oct 24, 1998·Trends in Neurosciences·C A Altar, P S DiStefano
Feb 5, 1999·Brain Research. Molecular Brain Research·H ShenK Chung
Feb 13, 1999·Progress in Neurobiology·M J Millan
Nov 19, 2003·Neuroscience Letters·Jean-Dominique DelcroixPaul Fernyhough
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Hafidi
Jun 18, 2003·Respiratory Physiology & Neurobiology·David M Katz
Jan 29, 2000·The European Journal of Neuroscience·X F ZhouJ H Zhong
May 5, 1999·Journal of Anatomy·G Terenghi
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KrüttgenE M Shooter
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S W ThompsonS B McMahon
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·R J MannionC J Woolf
Jul 20, 2002·Pancreas·Hiroki TomaPankaj J Pasricha
Mar 28, 1998·The European Journal of Neuroscience·X F ZhouR A Rush

Citations

Jan 1, 1978·Annual Review of Neuroscience·I B Black
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C WetmoreL Olson
Jul 1, 1989·Trends in Neurosciences·R W Oppenheim
Jun 1, 1989·Neuron·Y A Barde
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·H G KimB Lu

Related Concepts

Posterior Root of Spinal Nerve
Structure of Sciatic Nerve
Immunoreactivity
Malignant Neoplasm of Spinal Cord
Entire Nervous System
Recombinant Brain-Derived Growth Factors
Brain-Derived Neurotrophic Factor Measurement
Immune Sera
Neurotrophic factor
Nerve Endings

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.