Endogenous cell seeding. Remnant endothelium after stenting enhances vascular repair

Circulation
C RogersE R Edelman

Abstract

Endothelial integrity is essential for maintaining vascular homeostasis, and endothelial denudation results in neointimal thickening. Balloon-expandable endovascular stents provide a luminal scaffolding within atherosclerotic arteries with minimal direct contact between balloon and endothelium. We wondered whether stents cause diminished endothelial ablation, and if so, whether the degree of endothelial damage might determine later proliferative sequelae. Stainless steel stents were expanded in normal or previously denuded iliac arteries of New Zealand White rabbits. Stented arteries were harvested 15 minutes, 1 hour, 3 days, or 14 days later. En face staining of the luminal surfaces of stented arteries demonstrated that endothelial cell loss began immediately after stent expansion and was restricted to interstices between stent struts. Remnant endothelium adjacent to struts provided the foundation for complete endothelial regeneration of the stented segment within 3 days. Both early monocyte adhesion and later intimal macrophage accumulation were reduced > 80% in nonballooned but stented arteries, in concert with a twofold reduction in intimal thickening after 14 days, compared with arteries completely denuded with a balloon b...Continue Reading

References

Aug 1, 1992·Journal of the American College of Cardiology·S P KarasS B King
Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Aug 1, 1981·The Journal of Cell Biology·J J CastellotM J Karnovsky
Jun 1, 1980·Radiology·W R Castaneda-ZunigaK Amplatz
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E R EdelmanM J Karnovsky
May 28, 1993·Biochemical and Biophysical Research Communications·D B McNamaraD L Akers
Jan 1, 1958·The Journal of Pathology and Bacteriology·J C POOLEH W FLOREY

❮ Previous
Next ❯

Citations

Feb 7, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·I HerzY Adler
Aug 22, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·C CapozzoloM Chiariello
May 25, 2005·Annals of Biomedical Engineering·Taewon SeoAbdul I Barakat
Sep 19, 2009·Cardiovascular Drugs and Therapy·Bertram J JobstDaniel P Griese
May 26, 2009·JACC. Cardiovascular Interventions·John A OrmistonDonald S Baim
Oct 9, 2001·The American Journal of Cardiology·V MartíJ M Augé
Dec 14, 2001·The American Journal of Cardiology·D S BaimUNKNOWN PRE-Dilatation vs Direct Stenting In Coronary Treatment (PREDICT) Trial
Nov 27, 2002·The American Journal of Cardiology·Martin BrueckJosef Ludwig
Aug 16, 2000·Advanced Drug Delivery Reviews·S A Parikh, E R Edelman
Dec 29, 2000·Journal of the American College of Cardiology·D E DrachmanC Rogers
Jan 5, 2002·Journal of the American College of Cardiology·Christophe LoubeyrePierre Dumas
Jul 27, 2002·Journal of the American College of Cardiology·Carlo BriguoriAntonio Colombo
Dec 10, 2002·Journal of Vascular and Interventional Radiology : JVIR·Masao HamuroNorihumi Nishida
Feb 27, 2001·Tissue Engineering·J ZeltingerB Sibanda
Jan 23, 2003·The Journal of Cardiovascular Nursing·Dorie W Schwertz, Paul Vaitkus
Sep 20, 2002·Journal of Interventional Cardiology·Braim M RahelH W Thijs Plokker
Jan 21, 2011·Science Translational Medicine·Joseph W FransesElazer R Edelman
Aug 22, 2001·Heart·H Le BretonUNKNOWN Stent Without Balloon Predilation (SWIBAP) Study Group
Dec 7, 2011·Cancer Research·Joseph W Franses, Elazer R Edelman
Mar 3, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Iijima RaisukeHara Kazuhiro
Mar 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruo Inoue, Koichi Node
Oct 31, 2008·International Heart Journal·Tolga KocumOben Doven
Sep 9, 2004·Japanese Heart Journal·Cemal SagOben Baysan
Oct 11, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Eugene A Sprague, Julio C Palmaz
Jul 5, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Donny B Dal PonteStuart K Williams
Dec 6, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Samuel RobainaJames E Moore
Mar 24, 2006·AJR. American Journal of Roentgenology·Young-Cheol WeonDo Yun Lee
Feb 21, 2014·Journal of the Royal Society, Interface·Juan M JiménezPeter F Davies
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·C RogersD I Simon
Mar 16, 2001·The American Journal of Cardiology·D CarriéUNKNOWN Benefit Evaluation of Direct Coronary Stenting Study Group
Aug 22, 2006·Expert Review of Cardiovascular Therapy·Kunal SarkarJawahar L Mehta
Dec 16, 2006·Endothelium : Journal of Endothelial Cell Research·Annemarie M NoordeloosP W J C Serruys
May 22, 2010·Expert Opinion on Pharmacotherapy·Klaus A TirochAdnan Kastrati
Mar 8, 2003·International Journal of Cardiovascular Interventions·Chao-Wei HwangElazer R Edelman
Jan 29, 2016·Annals of Biomedical Engineering·Taewon SeoAbdul I Barakat
Apr 11, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yen-Hung LinUNKNOWN National Taiwan University Carotid Artery and Vertebral Artery Stenosis (NTU CAVAS) Study Group
Feb 3, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Julinda MehilliAlbert Schömig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.