Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium

Journal of the American College of Cardiology
K I IchikawaM Kawana

Abstract

We investigated the role of endogenous endothelin-1 in the development of cardiac hypertrophy in vivo under pressure overload conditions. Endothelin-1, a potent vasoconstrictor peptide, has recently been shown to act as a growth factor of myocardial cells in culture. We examined the effect of an endothelin-A receptor antagonist (FR139317) on the development of right ventricular hypertrophy in rats with monocrotaline-induced pulmonary hypertension. Three groups of rats were studied: those given monocrotaline alone or monocrotaline plus FR139317 and those given vehicle alone (control group). The ratio of right ventricular systolic pressure to aortic systolic pressure was similarly elevated in rats treated with monocrotaline and monocrotaline plus FR139317. The right ventricular/left ventricular weight ratio was increased in monocrotaline-treated rats but lower in rats treated with monocrotaline plus FR139317 than in those treated with monocrotaline alone (p < 0.01). As a biochemical marker of hypertrophy, the isoform ratio of beta-myosin heavy chain protein was determined for the right ventricular tissue samples. This ratio was increased in all monocrotaline-treated rats but was lower (p < 0.01) in rats given monocrotaline plus F...Continue Reading

References

Jan 1, 1992·Critical Reviews in Toxicology·D W WilsonD Morin
Mar 31, 1992·Biochemical and Biophysical Research Communications·D L WangC C Liew
Mar 31, 1989·Journal of Immunological Methods·N SuzukiM Fujino
Aug 1, 1989·Atherosclerosis·Y HirataF Marumo
Jul 14, 1988·The New England Journal of Medicine·M A PfefferE Braunwald
Jun 1, 1987·Circulation Research·V MahdaviB Nadal-Ginard
Apr 1, 1984·Forensic Science International : Synergy·H H HoppeP J Lincoln
Jan 1, 1993·Current Opinion in Nephrology and Hypertension·P J Mulrow
May 1, 1993·Circulation·E Morkin
Jul 1, 1992·Trends in Cardiovascular Medicine·R J HilkertT Quertermous

❮ Previous
Next ❯

Citations

Oct 30, 1998·European Journal of Clinical Investigation·P E MassartJ Donckier
Oct 20, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·A E Schultze, R A Roth
Sep 20, 2012·Endocrinology·Rongqin RenJohn A Cidlowski
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomoko UchinoKatsushige Ono
Jun 23, 2001·Drugs & Aging·M P Love, J J McMurray
Nov 24, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Paolo Verdecchia, Fabio Angeli
May 3, 2005·The Japanese Journal of Physiology·Takeshi HashimotoSadayoshi Taguchi
May 8, 2014·Current Hypertension Reports·Patrick R LawlerSusan Cheng
Jan 25, 2007·International Journal of Experimental Pathology·Hiroyuki HigashiyamaMine Kinoshita
Oct 13, 2005·Pharmacology & Therapeutics·Sophie MotteRobert Naeije
Feb 7, 2006·Pharmacology & Therapeutics·Friedrich BrunnerAdelino F Leite-Moreira
Jun 9, 2007·Current Opinion in Cardiology·Paolo VerdecchiaClaudio Cavallini
May 9, 2006·American Journal of Physiology. Heart and Circulatory Physiology·André P LourençoAdelino F Leite-Moreira
Apr 25, 2014·American Journal of Physiology. Cell Physiology·Mohammed Emehdi Atef, Madhu B Anand-Srivastava
Oct 14, 2020·Journal of Human Hypertension·Sunil K Nadar, Gregory Y H Lip
Aug 31, 2000·Journal of the American Society of Nephrology : JASN·Kerstin AmannEberhard Ritz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.