Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli

The Journal of Clinical Investigation
C A JaffeAriel L Barkan

Abstract

The roles of hypothalamic growth hormone-releasing hormone (GHRH) and of somatostatin (SRIF) in pharmacologically stimulated growth hormone (GH) secretion in humans are unclear. GH responses could result either from GHRH release or from acute decline in SRIF secretion. To assess directly the role of endogenous GHRH in human GH secretion, we have used a competitive GHRH antagonist, (N-Ac-Tyr1,D-Arg2)GHRH(1-29)NH2 (GHRH-Ant), which we have previously shown is able to block the GH response to GHRH. We first tested whether an acute decline in SRIF, independent of GHRH action, would release GH. Pretreatment with GHRH-Ant abolished the GH response to exogenous GHRH (0.33 microgram/kg i.v.) but did not modify the GH rise after termination of an SRIF infusion. We then investigated the role of endogenous GHRH in the GH responses to pharmacologic stimuli of GH release. The GH responses to arginine (30 g i.v. over 30 min), L-dopa (0.5 g orally), insulin hypoglycemia (0.1 U/Kg i.v.), clonidine (0.25 mg orally), or pyridostigmine (60 mg orally) were measured in healthy young men after pretreatment with either saline of GHRH-Ant 400 microgram/kg i.v. In every case, GH release was significantly suppressed by GHRH-Ant. We conclude that endogen...Continue Reading

References

Jul 1, 1979·Canadian Journal of Physiology and Pharmacology·J Kraicer
Oct 1, 1992·The Journal of Clinical Endocrinology and Metabolism·B M RobinsonA L Barkan
May 1, 1989·Clinical Endocrinology·J Alba-RothK von Werder
Dec 1, 1989·Journal of Endocrinological Investigation·J Alba-RothK von Werder
Jan 1, 1986·Annual Review of Physiology·Y C Patel, C B Srikant
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J Alba-RothK von Werder
Mar 1, 1986·The Journal of Clinical Endocrinology and Metabolism·K ChiharaT Fujita
Sep 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R RosskampA Tegeler
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·P TapanainenJ Leppäluoto
Jun 1, 1985·The Journal of Clinical Endocrinology and Metabolism·M DonnadieuJ C Job
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·C A JaffeA L Barkan

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Citations

Jan 2, 2007·Reviews in Endocrine & Metabolic Disorders·Eleni V Dimaraki, Craig A Jaffe
Sep 25, 1998·Physiology & Behavior·F ObálJ M Krueger
Sep 21, 2002·Molecular and Cellular Endocrinology·Kan LiuJeffrey E Kudlow
Aug 12, 2000·Psychoneuroendocrinology·M MokraniJ P Macher
Jul 6, 2000·Trends in Endocrinology and Metabolism : TEM·A L BarkanW F Young
Apr 1, 1997·Trends in Endocrinology and Metabolism : TEM·A L BarkanV Padmanabhan
Sep 19, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J C CarelJ L Chaussain
Sep 19, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S FiskerJ S Christiansen
Dec 18, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Andrew V SchallyJörg B Engel
Feb 21, 2009·Human Reproduction Update·Giuseppe FanciulliGiuseppe Delitala
May 6, 2011·Clinical Neuropharmacology·Thomas MüllerSiegfried Muhlack
Jul 3, 1998·The Journal of Clinical Investigation·C A JaffeA L Barkan
Mar 6, 2007·Endocrinology and Metabolism Clinics of North America·Naila Goldenberg, Ariel Barkan
Sep 26, 2014·The Tohoku Journal of Experimental Medicine·Zenei AriharaKazuhiro Takahashi
Sep 1, 1999·Clinical Endocrinology·S Chappel
Jul 11, 2008·Current Opinion in Critical Care·Beth E Taylor, Timothy G Buchman
Mar 2, 2006·Gerontology·Robert T RubinR Kenneth Czambel
May 22, 2007·Stress : the International Journal on the Biology of Stress·D JezovaM Vigas
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Hiralal G MaheshwariGerhard Baumann
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·C A JaffeA L Barkan
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Ralf NassMichael O Thorner
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Daniel E FlanaganRobert S Sherwin
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·E V DimarakiA L Barkan
Jul 27, 2000·Medicine and Science in Sports and Exercise· Maas HCMH P Koppeschaar
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Apr 3, 2003·American Journal of Physiology. Endocrinology and Metabolism·Eleni V DimarakiAriel L Barkan
Aug 13, 1999·The American Journal of Physiology·C A JaffeR Demott-Friberg
Jul 19, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leon S Farhy, Johannes D Veldhuis
Feb 16, 2021·Problemy e̊ndokrinologii·E L SorkinaA Barkan
Aug 22, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tal OronLiora Lazar

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