PMID: 7515265Feb 1, 1994Paper

Endogenous haemopoietic growth factors in neutropenia and infection

British Journal of Haematology
J CebonG Morstyn

Abstract

Haemopoietic growth factors (HGFs) are being administered to patients with neutropenic fever; however, little is known about the endogenous HGF response in these patients. Specific assays were used to study four HGFs, granulocyte (G-) CSF, granulocyte-macrophage (GM-) CSF, macrophage (M-) CSF and interleukin (IL-) 6 levels in the blood of patients with neutropenic fever (46 episodes). For comparison, levels were also measured in three control populations: normals (20), afebrile neutropenic (14), and bacteraemic but not neutropenic patients (20). In febrile patients, levels of G-CSF (median, range) (0.46, < 0.10-142 ng/ml). IL-6 (0.054, 0.005-24.3 ng/ml) and M-CSF (18.5, 9.9-79.1 ng/ml) were elevated compared with afebrile subjects (< 0.10, < 0.10-1.62 ng/ml). (0.008, 0.002-0.024 ng/ml) and (6.45, < 5.0-31.3 ng/ml) respectively. GM-CSF was not elevated (< 0.02, < 0.02-8.0 ng/ml) compared with afebrile subjects (0.021, < 0.02-0.20 ng/ml). Variables significantly associated (P < 0.05) with elevated cytokine levels were determined by multiple regression analyses. Factors associated with G-CSF elevation were fever, neutropenia, pathogen type and raised bilirubin and creatinine. In contrast, neutropenia was not associated with IL-6 e...Continue Reading

References

Sep 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·D W Golde, M J Cline
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D MetcalfM Li
Mar 1, 1990·Journal of Leukocyte Biology·M T LeeM B Ladner
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D Metcalf
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J S CebonG Morstyn
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
Feb 15, 1989·Annals of Internal Medicine·R H WeisbartD W Golde
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Van SnickR J Simpson
Jan 1, 1988·Immunology Today·A Cerami, B Beutler
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
Feb 3, 1972·The New England Journal of Medicine·P QuesenberryM Smith
Feb 1, 1968·The British Journal of Surgery·D E Sturdy
Jul 13, 1968·British Medical Journal·D Metcalf, B Wahren

❮ Previous
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Citations

Jan 1, 1996·Stem Cells·D J Kuter
Jan 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F Offner
Jul 19, 2012·World Journal of Microbiology & Biotechnology·F R GomesP L Ho
Jul 23, 2002·Trends in Immunology·John A Hamilton
Apr 17, 2008·Immunology and Cell Biology·Shalin H Naik
Dec 16, 2006·Nature Reviews. Immunology·Ken Shortman, Shalin H Naik
May 8, 1999·British Journal of Haematology·C YangD J Kuter
Aug 25, 1999·British Journal of Haematology·B JilmaO F Wagner
Nov 13, 2001·Diabetes, Obesity & Metabolism·A YönemA Corakçi
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R Kuritzkes
Dec 20, 1999·Journal of Hematotherapy & Stem Cell Research·M Foote, W Welch
Jun 1, 1997·Journal of Clinical Gastroenterology·F FataM S Cappell
Dec 1, 1995·British Journal of Haematology·P EngervallM Björkholm
May 3, 2013·PloS One·Cristina MunicioMariano Sánchez Crespo
Jul 6, 2006·World Journal of Surgical Oncology·Akio SakamotoYukihide Iwamoto
Oct 4, 2015·Brain, Behavior, and Immunity·Nadine HavensteinJoanna Fietz
Dec 1, 2009·Critical Care Clinics·Raghukumar ThirumalaSanjay Chawla
Jan 19, 2008·Biochemical and Biophysical Research Communications·Koji NomuraTetsuya Tomita
Jan 2, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Florian B MayrBernd Jilma
Oct 13, 2006·The Veterinary Journal·Emilio Fernández-Varón, Lucía Villamayor
Jul 21, 2005·Veterinary Immunology and Immunopathology·Keisuke OgumaAtsuhiko Hasegawa
Sep 1, 2015·Biomaterials·Knut RennertAlexander S Mosig
Mar 25, 2014·International Reviews of Immunology·Xin ShiPing Zhang
Aug 19, 2014·Cytokine & Growth Factor Reviews·Linda J Bendall, Kenneth F Bradstock
Feb 1, 1995·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Bo SöderquistTomas Vikerfors
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Peter KragsbjergDan Danielsson
Jun 1, 1996·Clinics in Chest Medicine·S Nelson, G J Bagby
Oct 31, 2000·Diabetes/metabolism Research and Reviews·M EdmondsA Foster
Dec 9, 2017·Cellular and Molecular Life Sciences : CMLS·Yukino ChibaTakayuki Yoshimoto
Nov 5, 1999·Critical Care Medicine·J H ReevesJ J Presneill
May 20, 2003·Scandinavian Journal of Infectious Diseases·Pavlos M MyrianthefsGeorge J Baltopoulos
Mar 15, 2005·Clinical and Experimental Immunology·M NoursadeghiJ Cohen

❮ Previous
Next ❯

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