Aug 10, 2015

Endogenous human stem cell-associated retroviruses

BioRxiv : the Preprint Server for Biology
Gennadi Glinsky

Abstract

Recent discoveries of endogenous human stem cell-associated retroviruses (SCARs) revealed consistent activation of specific endogenous retroviral elements in human preimplantation embryos and documented the essential role of the sustained retroviral activities in the maintenance of pluripotency, functional identity and integrity of naïve-state embryonic stem cells, and anti-viral resistance of the early-stage human embryos. SCARs activity have been implicated in seeding thousands’ human-specific regulatory sequences in the hESC genome. Activation of specific SCARs, namely LTR7/HERVH and LTR5_Hs/HERVK, has been demonstrated in patients diagnosed with multiple types of cancer, autoimmune diseases, neurodegenerative disorders and it is likely associated with the emergence of clinically lethal therapy resistant death-from-cancer phenotypes in a sub-set of cancer patients diagnosed with different types of malignant tumors.

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Mentioned in this Paper

Embryo
Retrovir
Laboratory Procedures
Genome
Thymic shared antigen-1
Cessation of Life
Neurodegenerative Disorders Pathway
Wasf1 protein, mouse
Cicatrix
Autoimmune Diseases

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