Endogenous Hydrogen Sulfide Enhances Carotid Sinus Baroreceptor Sensitivity by Activating the Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Channel

Journal of the American Heart Association
Wen YuHongfang Jin

Abstract

We aimed to investigate the regulatory effects of hydrogen sulfide (H2S) on carotid sinus baroreceptor sensitivity and its mechanisms. Male Wistar-Kyoto rats and spontaneously hypertensive rats (SHRs) were used in the experiment and were given an H2S donor or a cystathionine-β-synthase inhibitor, hydroxylamine, for 8 weeks. Systolic blood pressure and the cystathionine-β-synthase/H2S pathway in carotid sinus were detected. Carotid sinus baroreceptor sensitivity and the functional curve of the carotid baroreceptor were analyzed using the isolated carotid sinus perfusion technique. Effects of H2S on transient receptor potential cation channel subfamily V member 1 (TRPV1) expression and S-sulfhydration were detected. In SHRs, systolic blood pressure was markedly increased, but the cystathionine-β-synthase/H2S pathway in the carotid sinus was downregulated in comparison to that of Wistar-Kyoto rats. Carotid sinus baroreceptor sensitivity in SHRs was reduced, demonstrated by the right and upward shift of the functional curve of the carotid baroreceptor. Meanwhile, the downregulation of TRPV1 protein was demonstrated in the carotid sinus; however, H2S reduced systolic blood pressure but enhanced carotid sinus baroreceptor sensitivity...Continue Reading

References

Jul 19, 2001·Annals of the New York Academy of Sciences·M W ChapleauF M Abboud
Dec 16, 2003·Biochemical and Biophysical Research Communications·Hui YanChaoshu Tang
Jan 5, 2005·Biochemical and Biophysical Research Communications·Ying HanJunbao Du
Mar 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guangdong YangRui Wang
Oct 26, 2007·Acta Pharmacologica Sinica·Chang-qing ChenYi-zhun Zhu
Sep 27, 2008·Acta Pharmacologica Sinica·Hong-fang JinJun-bao Du
Mar 20, 2009·Molecular Pharmacology·Joris VriensBernd Nilius
Sep 4, 2009·The Journal of Pharmacology and Experimental Therapeutics·Hao SunHui-Lin Pan
Mar 2, 2010·Amino Acids·Hideo Kimura
Jul 3, 2013·Methods : a Companion to Methods in Enzymology·Changyuan LuSteven S Gross
Dec 19, 2013·British Journal of Pharmacology·Wen LuChuanyong Liu
Jun 26, 2014·Handbook of Experimental Pharmacology·Shunichi ShimizuYasuo Mori
Nov 22, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yan SunHongfang Jin
Dec 3, 2014·Biochemical and Biophysical Research Communications·Kazuki OhnoTakashi Uehara
Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yasunori TakayamaMakoto Tominaga
Jul 3, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Khadija M AlawiJulie E Keeble
Jul 8, 2015·Nature Reviews. Cardiology·Ronald G Victor
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Zhi-Zhong XieJin-Song Bian
Jul 15, 2016·Nature Communications·On-Chai LauXiaoqiang Yao
Nov 5, 2016·Free Radical Biology & Medicine·Daniel J DelloStrittoIan N Bratz

❮ Previous
Next ❯

Citations

Sep 22, 2017·Frontiers in Pharmacology·Da ZhangHongfang Jin

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.