PMID: 6111928Apr 11, 1981Paper

Endogenous hyperglycemia restores insulin release impaired by somatostatin analogue

The American Journal of Physiology
G J Taborsky, D Porte

Abstract

These studies assessed the ability of des-Asn5-[D-Trp8-D-Ser13]-somatostatin (d-ATS-SS) to selectively inhibit insulin release and produce a hyperglycemia sufficient to compensate for the original impairment. d-ATS-SS at 0.017 micrograms/min inhibited basal insulin output (delta = -38 +/- 6%, P less than 0.005) and increased basal pancreatic glucagon output (delta - +21 +/- 6%, P less than 0.05, n = 5). d-ATS-SS at 0.17 micrograms/min markedly inhibited insulin output (delta = -84 +/- 4%, P less than 0.0005) and slightly inhibited glucagon output (delta = -14 +/- 6%, P less than 0.05, n = 5). d-ATS-SS at 0.055 micrograms/min decreased basal and stimulated insulin release but not basal nor stimulated glucagon release. By 3.5 of analogue infusion, plasma glucose had risen by 116 +/- 13 mg/dl, and base-line insulin levels and the insulin responses to both isoproterenol and arginine, but not glucose, increased toward control values. We conclude that d-ATS-SS produces selective insulinopenia resulting in hyperglycemia which in turn compensates for the original impairment. Thus, the hyperglycemia observed in other states of selective insulin deficiency (e.g., noninsulin-dependent diabetes mellitus) may compensate for defects in beta-...Continue Reading

References

Oct 1, 1976·Physiological Reviews·R H Unger, L Orci
Jun 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J B Halter, D Porte
Sep 1, 1976·The Journal of Clinical Investigation·J P PalmerJ W Ensinck
Dec 1, 1976·The Journal of Clinical Investigation·A D CherringtonW W Lacy
Feb 11, 1976·The Journal of Clinical Endocrinology and Metabolism·J D BrunzellD Porte
Sep 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J W EnsinckR H Williams
Aug 1, 1972·The Journal of Clinical Investigation·R L Lerner, D Porte
Jan 1, 1974·The Journal of Clinical Investigation·J E LiljenquistG W Liddle
Dec 1, 1969·The Journal of Clinical Investigation·D Porte, A A Pupo

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