Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis

Journal of the American Society of Nephrology : JASN
A R KitchingS R Holdsworth

Abstract

IL-13 is produced by T helper 2 (Th2) cells, has a role in stimulating Th2-mediated injury, alters humoral responses, and may directly suppress macrophage and neutrophil function. In immune renal disease, the engagement of different effector mediator systems, including humoral and cell-mediated effectors, can result in glomerular injury. Experimental crescentic glomerulonephritis (known as autologous anti-glomerular basement membrane glomerulonephritis) induced by planting an antigen in glomeruli of mice is Th1 directed, delayed-type hypersensitivity (DTH)-like, and antibody independent. To test the hypothesis that, like the counterregulatory Th2 cytokines IL-4 and IL-10, endogenous IL-13 limits effector Th1 responses in glomerulonephritis, crescentic glomerulonephritis was induced in IL-13+/+ and IL-13-/- mice. Although IL-13-/- mice developed increased serum antigen-specific antibody levels, increased glomerular antibody deposition and enhanced switching to the Th1-associated IgG2a subclass, they developed a similar degree of crescentic glomerulonephritis, with similar glomerular T cell/macrophage numbers, renal impairment, and proteinuria. Antigen-specific dermal DTH and IFN-gamma production by antigen-stimulated splenocytes...Continue Reading

Citations

Oct 24, 2007·Seminars in Immunopathology·Christian KurtsJürgen Floege
Mar 21, 2008·Kidney International·M SandoviciL E Deelman
Oct 20, 2005·Clinical and Experimental Immunology·P G Tipping, A R Kitching
Jan 4, 2015·Journal of the American Society of Nephrology : JASN·Qingsong HuangQi Cao
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming LiA Richard Kitching
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P KuligowskiMichael J Hickey
Jan 4, 2018·Journal of the American Society of Nephrology : JASN·Qi CaoDavid C H Harris

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