Endogenous inhibition of arachidonic acid metabolism in the endometrium of the sheep

Prostaglandins, Leukotrienes, and Essential Fatty Acids
S Basu

Abstract

Arachidonic acid is metabolised via the cyclo-oxygenase pathway to several biologically active metabolites. These metabolites control important reproductive functions like luteolysis of the corpus luteum. The metabolism of arachidonic acid was studied by the enzymatic conversion of [1-14C]-labelled arachidonic acid in sheep endometrial tissue. The inhibitory capacity of sheep endometrial tissue was measured by the enzymatic conversion of [1-14C]-arachidonic acid by sheep seminal vesicular gland microsomes. Endometrial microsomes converted arachidonic acid into different prostaglandins and monohydroxy acids but at a low rate. A factor(s) inhibiting both prostaglandin and monohydroxy acid synthesis was found in both the microsomal and cytosolic fractions of endometrial tissue. A very high inhibitory potency of prostaglandin and monohydroxy acid synthesis, calculated as IC50 values, was found in cytosolic fractions. For comparison IC50 values of indomethacin, mefenamic acid, carprofen and acetylsalicylic acid were also calculated in this in vitro system. These data indicate that both prostaglandin and monohydroxy acid synthesizing capacities and an inhibitory factor(s) are present in sheep endometrium and possibly regulate arachid...Continue Reading

References

Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Nov 3, 1977·Nature·S A SaeedH O Collier
Oct 1, 1976·Physiological Reviews·E W Horton, N L Poyser
Feb 20, 1975·Biochimica Et Biophysica Acta·D H Nugteren
Jan 1, 1975·Annual Review of Biochemistry·B SamuelssonS Hammarström
May 1, 1975·Angewandte Chemie·W Bartmann
May 1, 1987·Prostaglandins, Leukotrienes, and Medicine·M D MitchellJ A Hunter
Feb 1, 1988·Zentralblatt für Veterinärmedizin. Reihe A·S BasuH Kindahl
Aug 11, 1972·Biochimica Et Biophysica Acta·E J Christ, D A van Dorp
Aug 2, 1972·Nature: New Biology·J A McCrackenB Samuelsson
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Apr 30, 1971·Annals of the New York Academy of Sciences·J McCracken
Nov 28, 1980·Science·F A Kuehl, R W Egan
Jan 1, 1983·Annual Review of Biochemistry·S Hammarström

❮ Previous
Next ❯

Citations

Mar 15, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J HelmerssonS Basu
Jan 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P R GrayM L Peters-Golden
Sep 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N L Poyser
Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·K OdensvikH Kindahl
Mar 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·J K Findlay, L A Salamonsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.