Endogenous inhibitors of RNA interference in Caenorhabditis elegans

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
L Timmons

Abstract

In eukaryotes, double-stranded RNAs (dsRNAs) or short, interfering dsRNAs (siRNAs) can reduce the accumulation of a sequence-related mRNA, often resulting in a loss-of-function phenotype-a process termed RNA interference (RNAi). Unfortunately, some mRNAs are resistant to the effects of dsRNA. Experiments designed to unravel RNAi mechanisms in Caenorhabditis elegans have led to the identification of two worm proteins, RRF-31,2 and, now, ERI-1,3 that can inhibit RNAi responses. Animals defective in either protein can display enhanced RNAi phenotypes for mRNAs that were previously resistant to dsRNA. Since ERI-1 is a conserved protein, development of procedures to enhance RNAi effectiveness in other systems may be possible.

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Citations

Nov 13, 2007·Journal of Bioenergetics and Biomembranes·Lisa D Timmons
Apr 29, 2008·Nature Structural & Molecular Biology·K Mark AnselVigo Heissmeyer
Nov 29, 2013·International Journal of Molecular Sciences·Sudipta ChakrabortyMichael Aschner
Aug 1, 2014·Nature·Silvia CaloJoseph Heitman
Dec 7, 2007·Molecular and Biochemical Parasitology·Kevin T MilitelloManoj T Duraisingh
Jul 19, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Anders Fjose, Oyvind Drivenes
Sep 13, 2017·BMC Evolutionary Biology·Santiago FontenlaJose F Tort
Dec 31, 2020·Molecular Cell·Daniel A ChavesWeifeng Gu

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