Endogenous interleukin-4, but not interleukin-10, is involved in suppression of host resistance against Listeria monocytogenes infection in interferon-depleted mice.

Infection and Immunity
A NakaneT Minagawa

Abstract

The production and roles of endogenous interleukin-4 (IL-4) and IL-10 in a sublethal infection with Listeria monocytogenes were studies in normal mice and anti-gamma interferon (IFN-gamma) monoclonal antibody (MAb)-pretreated mice. In normal mice, the expression of mRNAs for IL-4 and IL-10, which was amplified by reverse transcription-PCR, was induced in the spleens and livers either early or late in infection, although the serum IL-4 and IL-10 were not detectable by enzyme-linked immunosorbent assays. In vivo administration of anti-IL-4 MAb showed no effect on antilisterial resistance, whereas anti-IL-10 MAb partially diminished the defense. In anti-IFN-gamma MAb-pretreated mice, a delay in the bacterial elimination from the spleens and livers was observed and high titers of serum IL-4 and IL-10 were induced late in infection. Production of endogenous IL-4 and IL-10 was suppressed in both CD4+ cell-and CD8+ cell depleted mice. The suppression of antilisterial resistance in anti-IFN-gamma MAb-pretreated mice was canceled when anti-IL-4 MAb was injected late in infection, whereas anti-IL-10 MAb showed no effect. These results suggest that the host immune responses were polarized into the T-helper 2 phenotype in anti-IFN-gamma MA...Continue Reading

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Citations

Jun 11, 1999·FEMS Microbiology Letters·A NakaneT Miura
Sep 5, 2014·Nihon saikingaku zasshi. Japanese journal of bacteriology·Akio Nakane
Sep 14, 2001·Scandinavian Journal of Immunology·M C SouzaZ P Camargo
Oct 21, 2006·Microbiology and Immunology·Tadaatsu ImaizumiKei Satoh
Jul 31, 2004·Immunology and Cell Biology·María A PuertollanoGerardo Alvarez De Cienfuegos
Apr 17, 1998·FEMS Immunology and Medical Microbiology·A NakaneT Minagawa
Mar 6, 1998·Infection and Immunity·S SasakiA Nakane
Jul 13, 2000·FEMS Immunology and Medical Microbiology·T MiuraA Nakane
Nov 7, 2000·FEMS Immunology and Medical Microbiology·K YamadaA Nakane
Nov 11, 2006·Biochemical and Biophysical Research Communications·Hiroshi SashinamiAkio Nakane
Jan 24, 2007·Biochemical and Biophysical Research Communications·Fuyuki SatoHiroshi Kijima

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