Endogenous lectins in chickens and slime molds: transfer from intracellular to extracellular sites

Journal of Supramolecular Structure and Cellular Biochemistry
S H BarondesD N Cooper

Abstract

Endogenous lectins in both cellular slime molds and chicken tissues have been localized primarily intracellularly, in contrast with the predominantly extracellular localization of the glycoproteins, glycolipids, and glycosaminoglycans with which they might interact. Here we present evidence that lectins in both of these organisms may be externalized and become associated with the cell surface and/or extracellular materials. In chicken intestine, chicken-lactose-lectin-II is shown to be localized in the secretory granules of the goblet cells, along with mucin, and to be secreted onto the intestinal surface. In embryonic muscle, chicken-lactose-lectin-I is shown to be externalized with differentiation, ultimately becoming localized on the surface of myotubes and in the extracellular spaces. In a cellular slime mold, Dictyostelium purpureum, externalization of lectin is elicited by either polyvalent glycoproteins that bind the small amount of endogenous cell surface lectin, or by slime mold or plant lectins that bind unoccupied complementary cell surface oligosaccharides. These results suggest that externalization of endogenous lectin may be a response to specific external signals. We conclude that lectins are frequently held in i...Continue Reading

References

Aug 1, 1979·The Journal of Cell Biology·E C BeyerS H Barondes
Jan 1, 1979·Journal of Supramolecular Structure·H CeriS H Barondes
Mar 16, 1978·Nature·F J Mir-Lechaire, S H Barondes
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S D RosenS H Barondes
Jan 1, 1980·Journal of Supramolecular Structure·E C Beyer, S H Barondes
Jan 1, 1981·Annual Review of Biochemistry·S H Barondes
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·M M RobersonS H Barondes

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Citations

Jan 1, 1992·Developmental and Comparative Immunology·R GotoH Kamiya
Jan 1, 1983·The Journal of Cell Biology·S H BarondesP L Haywood-Reid
Aug 1, 1987·Archives of Biochemistry and Biophysics·H J AllenR A DiCioccio
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·M M RobersonS H Barondes

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