PMID: 11904604Mar 21, 2002Paper

Endogenous mast cell degranulation modulates cervical contractility in the guinea pig

American Journal of Obstetrics and Gynecology
Egle BytautieneRobert E Garfield

Abstract

The purpose of this study was to investigate the effect of endogenous mast cell degranulation on the contractility of isolated cervical strips from nonpregnant and pregnant guinea pigs. Longitudinal cervical strips from nonpregnant and pregnant (mid and term) guinea pigs were used for isometric tension recording. Responses to the mast cell degranulating agent, compound 48/80, were compared in the absence or presence of different inhibitors and receptor antagonists. Concentration-response curves were obtained to histamine and 5-hydroxytryptamine in strips that were incubated with antagonists or solvent. Compound 48/80 and histamine significantly increased contractility of cervical strips in all 3 groups of animals. The inhibitor of mast cell degranulation significantly reduced responses to compound 48/80 and histamine-1 receptor antagonist reduced responses to histamine in all 3 groups. Histamine-1 receptor antagonist significantly inhibited responses to compound 48/80 in nonpregnant and mid pregnant guinea pigs. Histamine-2 receptor antagonist did not alter responses to compound 48/80 nor to histamine. The receptor antagonist 5-hydroxytryptamine-2 significantly inhibited cervical contractility that was induced by compound 48/80...Continue Reading

References

Jan 1, 1989·Gynecologic and Obstetric Investigation·M A CruzM I Rudolph
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A NorströmB Lindblom
Jun 1, 1994·Cell and Tissue Research·J S MarshallJ Bienenstock
Dec 1, 1993·British Journal of Obstetrics and Gynaecology·M I RudolphL Bardisa
Feb 1, 1997·Human Reproduction·A MoriS Fujii
May 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H SpanggaardC C Danielsen
Oct 23, 1998·Molecular Human Reproduction·E EkerhovdA Norström
Aug 2, 2000·American Journal of Obstetrics and Gynecology·R E GarfieldR Romero

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Citations

Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·J VarayoudE H Luque
Jun 24, 2014·Cellular & Molecular Immunology·Nardhy Gomez-LopezMarcia Arenas-Hernandez
Oct 28, 2008·European Journal of Pharmacology·Tatsuro NakamuraTetsuro Taneike
Sep 23, 2009·Reproduction in Domestic Animals = Zuchthygiene·E van EngelenV P M G Rutten
Jan 9, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·R RomeroM Mazor
Nov 13, 2008·Paediatric and Perinatal Epidemiology·Lisa M Bodnar, Hyagriv N Simhan
Nov 10, 2011·Reproduction in Domestic Animals = Zuchthygiene·Y X LiuH Z Liu
Jun 17, 2011·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·M ManeraB S Dezfuli
Jan 3, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nele FreerksenRobert Garfield
Aug 30, 2008·American Journal of Obstetrics and Gynecology·Egle BytautieneRobert E Garfield
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Egle BytautieneRobert E Garfield
Nov 18, 2004·American Journal of Obstetrics and Gynecology·Egle BytautieneRobert E Garfield
Mar 14, 2003·American Journal of Obstetrics and Gynecology·Egle BytautieneRobert E Garfield
Mar 19, 2014·Animal Reproduction Science·Abhishek SharmaSatish Kumar Garg
Nov 18, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicSonia S Hassan
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kelly J Plaku, Pierre-Yves von der Weid
Dec 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca GotschLami Yeo
Nov 11, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroLami Yeo
Jun 19, 2013·Journal of Perinatal Medicine·Jennifer Lam-RachlinTinnakorn Chaiworapongsa
Aug 26, 2006·Reproduction, Fertility, and Development·Jennifer L ScottPhillip M Summers

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