Endogenous mediators that inhibit the leukocyte-endothelium interaction

Trends in Pharmacological Sciences
M Perretti

Abstract

Leukocyte extravasation occurs in many pathophysiological conditions, including inflammation, neoplasia and asthma. In recent years many studies have elucidated the steps that promote the initial interaction between extravasating cells and endothelium of the post-capillary venule; the sequential role of several classes of adhesion molecules (cell-specific chemokines) and activators (multipotent cytokines) is well established. In this review, Mauro Perretti focuses on a less well investigated mechanism by which the host downregulates extravasation at the leukocyte-endothelium interface. The neutrophilic polymorphonuclear leukocyte is used as the prime example of a leukocyte that interacts with the endothelium, and particular emphasis is given to the possibility that novel anti-inflammatory therapies might be developed from a better understanding of the inhibitory mechanisms activated by endogenous mediators such as adenosine, lipocortin 1, NO, prostacyclin and cathepsin G.

References

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Citations

Nov 11, 2003·Trends in Pharmacological Sciences·Mauro Perretti
Aug 14, 2003·Trends in Pharmacological Sciences·Lucia SpicuzzaRiccardo Polosa
Feb 26, 2000·Trends in Pharmacological Sciences·T M Cocks, J D Moffatt
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·L H LimM Perretti
Dec 7, 2002·Mediators of Inflammation·Sonia M OlianiMauro Perretti
Feb 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanJohn L Wallace
Sep 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giovanna LeoniMauro Perretti
May 31, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Diane S Allen-GipsonTodd A Wyatt
Sep 24, 2010·PloS One·Derek RenshawMauro Perretti
Aug 31, 2000·Microvascular Research·X NiR F Tuma
Oct 5, 2001·The American Journal of Pathology·C de CoupadeE Solito
Feb 13, 2001·The American Journal of Pathology·S M OlianiM Perretti
Jun 16, 2010·Pharmacology & Therapeutics·Neil Dufton, Mauro Perretti
Oct 3, 2006·Current Opinion in Anaesthesiology·D K Menon, A C Summors
Dec 5, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Joselina Maria da SilvaAmílcar Sabino Damazo
May 30, 2006·Diabetes·Françoise Homo-DelarchePatricia Serradas
May 21, 2016·Frontiers in Immunology·Michelle A SugimotoMauro M Teixeira

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