PMID: 6170739Oct 1, 1981Paper

Endogenous myelin basic protein-serum factors (MBP-SFs) and anti-MBP antibodies in humans. Occurrence in sera of clinically well subjects and patients with multiple sclerosis

Journal of the Neurological Sciences
P Y PatersonD H Harter

Abstract

Sera of normal subjects and patients wtih multiple sclerosis (MS) have been frequently found to contain picomolar quantities of endogenous myelin basic protein-serum factors (MBP-SFs). These serum factors, collectively representing a heterogeneous spectrum, were detected and measured by means of a competitive inhibition radioimmunoassay (RIA) designed to distinguish their respective binding affinities with anti-MBP reagent antiserum. Anti-MBP antibodies in these same normal and patient sera were also detected and their differing binding affinities determined. In general, when sera of normal subjects were found to contain free MBP-SFs, the reagent anti-MBP antibodies in the reagent antiserum used to detect them were of relatively high binding affinity (8 X 10(8) M-1). When normal sera were found to contain free anti-MBP antibodies, the affinities of such antibodies were invariably lower (0.06-0.7 X 10(8) M-1). In contrast, sera of patients with active MS and exhibiting clinical fluctuations in their disease, infrequently contained high or medium high affinity MBP-SFs, whereas higher affinity anti-MBP antibodies were commonly detected. These patterns of MBP-SFs and anti-MBP antibodies in normal and MS human sera resemble those pr...Continue Reading

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Citations

Jan 15, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stephanie C JoachimFranz H Grus
May 1, 1983·Journal of the Neurological Sciences·B Ryberg
Oct 1, 1986·Journal of Neuroimmunology·N P GroomeE C Alvord
Oct 16, 2002·Journal of Immunological Methods·Natalya A PonomarenkoAlexander G Gabibov
May 26, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·B O Khatri
Jan 1, 1981·Immunological Reviews·P Y PatersonC C Whitacre
Jun 1, 2006·Expert Review of Neurotherapeutics·Francesco LolliAnna Maria Papini
Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·M K Gupta
May 27, 2003·The Spanish Journal of Psychology·Francisco Nievas, Fernando Justicia
Dec 1, 1984·Annals of Neurology·P K Coyle, Z Procyk-Dougherty
Jan 1, 1991·Journal of Clinical Apheresis·A M Rostami

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