Endogenous neurogenesis in the hippocampus of developing rat after intrauterine infection

Brain Research
Peifang JiangHui-Min Yu

Abstract

Perinatal infection is a major cause of neonatal neurologic morbidity. The goal of this study is to examine the effects of intrauterine infection on hippocampal neurogenesis and self-repair during early developmental stages. The animals were randomly divided into two groups: E. coli infected group and control group. Neurogenesis was examined by incorporation of BrdU, a marker of proliferating cells and their progeny. Rats were sacrificed on P3, P7, P14 and P28, and their brains were prepared for histological analysis of cell proliferation. To evaluate hippocampus neurogenesis, rats were sacrificed on P7 and P28, and their brains were prepared for evaluation of newly generated neural stem cells using double labeling of BrdU and Nestin, newly formed neurons using double labeling of BrdU and NeuN, and newly formed astrocytes using double labeling of BrdU and GFAP. In intrauterine E. coli infected group, there was significant increase in numbers of BrdU-labeled cells (about 2-fold at P7) than that of the control group (P<0.05). Confocal microscopy showed that there was a significant difference in BrdU/Nestin coexpression between the control and E. coli infected groups (P<0.01). Evaluation of the phenotype of the surviving cells sho...Continue Reading

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Citations

Jan 28, 2014·Neuroscience and Biobehavioral Reviews·Holly F Green, Yvonne M Nolan
Feb 28, 2015·European Archives of Psychiatry and Clinical Neuroscience·Peifang JiangHuimin Yu
Apr 9, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Peifang JiangHuimin Yu
Feb 26, 2021·Experimental Neurology·Diego Bulcão ViscoRaul Manhães-de-Castro
Jun 8, 2018·Science Translational Medicine·Isis Nem de Oliveira SouzaJulia R Clarke

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