Endogenous nitric oxide modulates behavioural effects elicited by substance P in rat

European Journal of Pharmacology
F MancusoL Sorrentino

Abstract

Several studies have shown that the undecapeptide, substance P, alters behaviour following central or peripheral administration in the rat. Here we report that L-arginine administration increases substance P-induced locomotion and changes in food intake in rats. NG-Nitro-L-arginine methyl ester, a specific inhibitor of nitric oxide synthase, reduces substance P-induced effects. These results suggest that endogenous nitric oxide plays a role in the modulation of the catecholaminergic effect of substance P on motor behaviour. They also clarify the mechanism underlying food intake induced by substance P.

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Citations

Mar 29, 2001·Behavioural Brain Research·I P BarettaT C De Lima
Oct 23, 1997·Behavioural Brain Research·E DzoljicM R Dzoljic
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen SammutAnthony R West
Mar 10, 2007·Medicinski pregled·Eleonora DzoljićMilica Prostran

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