Endogenous norepinephrine regulates blood flow to the intact rat tibia

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
J B A FeitelsonJ T Fleming

Abstract

The goal of our study was to determine if endogenous norepinephrine (NE) has a role in the regulation of basal blood flow to intact bone. The experimental plan was to measure bone blood flow before and after pharmacological blockade of alpha-adrenergic receptors. A significant increase in blood flow after receptor blockade would suggest that endogenous norepinephrine exerts a tonic constrictor effect on the vessels supplying blood to the bone. Mature, male rats were anesthetized with Inactin. Arterial blood pressure and left tibia blood flow (laser Doppler flowmetry) were measured. A cannula was inserted into the right iliac artery and advanced to the aortic bifurcation to deliver drugs into the left hindlimb circulation, including the left tibia vasculature. Bolus injection of norepinephrine caused a dose-dependent decrease in bone blood flow (30-40%). Blockade of alpha-adrenergic receptors with phentolamine or phenoxybenzamine attenuated by more than 50% the norepinephrine-induced decrease in bone blood flow. In separate rats that had not received exogenous norepinephrine, injection of phentolamine alone decreased bone vascular resistance by 34+/-3%. Similarly, phenoxybenzamine decreased resistance by 25+/-4%. These results a...Continue Reading

References

Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T R DavisP M Vanhoutte
May 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T R Davis, M B Wood
Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M T DeanP M Vanhoutte
Jun 1, 1968·The Journal of Bone and Joint Surgery. American Volume·S S Shim
Jul 1, 1969·Journal of Gerontology·Z Hruza, M Wachtlova
Sep 1, 1984·Calcified Tissue International·R DaviesS P Hughes
May 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C G MoranM B Wood
Jul 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G S LaustenB Dahl
May 1, 1997·British Journal of Pharmacology·W R FerrellS M Karimian
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D DiwanG A Murrell
Jan 12, 1963·JAMA : the Journal of the American Medical Association·N M TROTMAN, W D KELLY

❮ Previous
Next ❯

Citations

May 30, 2013·Current Hypertension Reports·Monica M SantistebanMohan K Raizada
Jan 17, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Paul A DabischPhilip J Kadowitz
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J B A FeitelsonJ T Fleming
Aug 11, 2005·Journal of Applied Toxicology : JAT·Leena PradhanPhilip J Kadowitz
Sep 10, 2020·Frontiers in Endocrinology·Rafiye Ciftciler, Ibrahim Celalettin Haznedaroglu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.