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Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Acta Neuropathologica

Apr 24, 2019

Panagiota MavroeidiMaria Xilouri

Abstract

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendrog...read more

Mentioned in this Paper

In Vivo
Research
Methanesulfonic Acid Monooxygenase Activity
Knock-out
Brain
SNCA
Pyridoxal Phosphate
SNCA wt Allele
Microtubules
LCN2 protein, human
3
2
21
Paper Details
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Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Acta Neuropathologica

Apr 24, 2019

Panagiota MavroeidiMaria Xilouri

PMID: 31011860

DOI: 10.1007/s00401-019-02014-y

Abstract

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendrog...read more

Mentioned in this Paper

In Vivo
Research
Methanesulfonic Acid Monooxygenase Activity
Knock-out
Brain
SNCA
Pyridoxal Phosphate
SNCA wt Allele
Microtubules
LCN2 protein, human
3
2
21

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