PMID: 7164001Nov 1, 1982Paper

Endogenous opiates and the control of breathing in normal subjects and patients with chronic airflow obstruction

Thorax
M V TabonaP J Barnes

Abstract

To investigate the role of endorphins in central respiratory control, the effect of naloxone, a specific opiate antagonist, on resting ventilation and ventilatory control was investigated in a randomised double-blind, placebo-controlled study of normal subjects and patients with chronic airways obstruction and mild hypercapnia due to longstanding chronic bronchitis. In 13 normal subjects the ventilatory response to hypercapnia increased after an intravenous injection of naloxone (0.1 mg/kg), ventilation (VE) at a PCO2 of 8.5 kPa increasing from 55.6 +/- SEM 6.2 to 75.9 +/- 8.21 min-1 (p less than 0.001) and the delta VE/delta PCO2 slope increasing from 28.6 +/- 4.4 to 34.2 +/- 4.21 min-1 kPa-1 (p less than 0.05). There was no significant change after placebo (saline) injection. Naloxone had no effect on resting ventilation or on the ventilatory response to hypoxia in normal subjects. In all six patients naloxone significantly (p less than 0.02) increased mouth occlusion pressure (P 0.1) responses to hypercapnia. Although there was no change in resting respiratory frequency or tidal volume patients showed a significant (p less than 0.01) decrease in inspiratory timing (Ti/Ttot) and increase in mean inspiratory flow (VT/Ti) after...Continue Reading

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SimantovS H Snyder
Jun 9, 1977·Nature·J A LordH W Kosterlitz
Jul 14, 1977·The New England Journal of Medicine·A J BergerJ W Severinghaus
Apr 1, 1977·Thorax·D H LedererN S Cherniack
Jul 1, 1976·Chest·J Milic-Emili, M M Grunstein
Nov 13, 1975·The New England Journal of Medicine·J Milic-EmiliJ P Derenne
May 22, 1975·The New England Journal of Medicine·J V WeilI E Sodal
Feb 18, 1980·Life Sciences·M W Adler
Apr 1, 1980·Pediatric Research·V ChernickE E Lawson

Citations

Feb 27, 1984·Life Sciences·R A SteinbrookS E Weinberger
Jul 1, 1985·Respiration Physiology·T RochatR C Gaillard
Feb 1, 1991·Respiration Physiology·M Pokorski, S Lahiri
Oct 1, 1990·The American Review of Respiratory Disease·J E ShookE M Camporesi
Jan 1, 1988·Chest·S B Reents, C A Beck
Apr 12, 2000·The American Journal of Cardiology·A Y SaadjianR Guieu
Aug 26, 2014·Complementary Therapies in Medicine·Woung-Ru TangSien-Hung Yang
Feb 1, 1997·Journal of Applied Physiology·H E GreenbergS M Scharf

Related Concepts

Bronchitis
Double-Blind Method
Endorphins
Hypercapnia
Lung Diseases, Obstructive
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Randomization
Respiration
Respiratory Function Tests

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