PMID: 3214943May 1, 1988Paper

Endogenous opioids inhibit oxytocin release during nicotine-stimulated secretion of vasopressin in man

Clinical Endocrinology
J R SecklS L Lightman

Abstract

The effects of the opioid antagonist naloxone on the vasopressin (AVP) and oxytocin (OT) responses to nicotine were studied in male non-smokers (21-30 years old). Either saline (n = 6) or naloxone (4 mg bolus + 6 mg/h, n = 6) was infused i.v. during the study. After 60 min infusion the subjects smoked one high-nicotine content cigarette. Naloxone infusion for 60 min did not alter basal plasma AVP or OT levels. Smoking led to a significant rise in plasma vasopressin in both saline and naloxone-infused subjects (P less than 0.05). There was no significant difference in the plasma AVP response to smoking between the two groups. Saline-infused subjects did not show any change in plasma OT in response to smoking. Naloxone infusion was associated with a significant rise in OT from 1.3 +/- 0.1 pmol/l to 4.3 +/- 2.4 pmol/l 5 min after smoking (P less than 0.05). We conclude that there is endogenous opioid-mediated inhibition of OT which prevents its release when AVP is secreted in response to nicotine in man.

References

Oct 1, 1979·The Journal of Clinical Endocrinology and Metabolism·P T PullanC I Johnston
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M R MurphyS L Lightman
Jan 1, 1986·The Journal of Endocrinology·T D WilliamsS L Lightman
Oct 1, 1985·The Journal of Endocrinology·M D StonehamK Todd
Apr 2, 1982·Science·S J WatsonT B van wimersma Griedanus
Oct 1, 1983·Physiological Reviews·A H Sklar, R W Schrier
Apr 1, 1982·Clinical Endocrinology·S LightmanM Forsling

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Citations

Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·D H MalinO B Wilson
Jul 1, 1996·Pharmacology, Biochemistry, and Behavior·D H MalinO B Wilson
Jun 8, 2011·International Breastfeeding Journal·Alia M Heise, Diane Wiessinger
Aug 2, 2011·Frontiers in Neuroendocrinology·Nadine StriepensRené Hurlemann

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