Endogenous opioids suppress activation of nociceptors by sub-nanomolar nicotine

British Journal of Pharmacology
F J MiaoJ D Levine

Abstract

1. Nicotine can activate primary afferent nociceptors, one result of which is to increase neurogenic plasma extravasation. In this study we have demonstrated a novel proinflammatory effect of sub-nanomolar nicotine, mediated by peripheral action at sensory neurons. This action is normally masked by adrenal medulla-derived delta-opioid receptor agonists. 2. While neurogenic plasma extravasation in the knee joint of the rat was not increased by intra-articular perfusion of nicotine (10(-8) M), perfusion of nicotine, at concentrations as low as 10(-10) M, combined with naloxone to block opioid receptors (or naltrindole to block delta-opioid receptors) was able to enhance bradykinin-induced plasma extravasation. This pro-inflammatory effect of intra-articular nicotine was mimicked by subcutaneous nicotine which was abolished by intra-articularly-administered hexamethonium, a nicotinic receptor antagonist. 3. Following denervation of the adrenal medulla, intra-articular nicotine, alone at 10(-8) M, enhanced plasma extravasation, which was no longer enhanced by naloxone. 4. Destruction of primary afferents by neonatal treatment with capsaicin or blockade of sensory neurotransmitter by neurokinin-1 receptor antagonist RP-87,580 abolis...Continue Reading

References

Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S R HamannW R Martin
Jan 1, 1991·Journal of Neurobiology·R T BoydD K Berg
Sep 25, 1986·Neuroscience Letters·B PrzewłockaA M Coenen
Nov 24, 1995·Science·A TaddeseE W McCleskey
Jul 31, 1995·Neuroreport·R G RobertsJ Pennefather
Jan 1, 1994·Life Sciences·A V Terry, M S Clarke
Aug 1, 1996·American Industrial Hygiene Association Journal·T A BergmanR J Rando
Apr 8, 1998·Journal of Occupational and Environmental Medicine·D TroutJ Pirkle
Jun 6, 1998·Journal of Applied Physiology·W G Mayhan, G M Sharpe
Aug 26, 1999·Journal of Neurochemistry·R JanákyC A Shaw
Aug 1, 1964·The Australian Journal of Experimental Biology and Medical Science·J CARR, D L WILHELM

❮ Previous
Next ❯

Citations

Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jul 24, 2004·The Journal of Physiology·David O WarnerNisha Charkoudian
May 27, 2008·British Journal of Pharmacology·I Wessler, C J Kirkpatrick
Dec 18, 2003·The Journal of Physiology·Frederick Jia-Pei MiaoJon D Levine
Aug 21, 2008·Anesthesia and Analgesia·Neal L Benowitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.