Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats

Prostaglandins
C H ChoS K Lam

Abstract

The involvement of endogenous prostaglandins (PGs) in modulating gastric mucosal blood flow (GMBF) is still unclear. The present study was designed to demonstrate the role of this autacoid in the basal GMBF and the restoration of blood flow after restriction of blood supply to the stomach. The ex-vivo gastric chamber was prepared and the GMBF was measured by a laser Doppler technique. 20% ethanol incubation for 10 min in the chamber increased the basal GMBF and lessened the reduction of blood flow induced by absolute ethanol. It also decreased lesion formation caused by ethanol. Indomethacin 5 mg/kg, given s.c 60 min before experimentation had the opposite effects. Ligation of the gastric artery for 20 min which reduced the GMBF by 60%, worsened ethanol ulceration. There was a marked rebound of the GMBF after the ligation was released. Indomethacin totally abolished the blood flow rebound and aggravated ethanol ulceration. However, 20% ethanol incubation significantly potentiated such a rebound in blood flow and reduced lesion formation. Indomethacin pretreatment reversed these actions, whereas misoprostol administration produced the similar effects as 20% ethanol. It is concluded that GMBF plays an important role in ethanol ul...Continue Reading

References

Jul 1, 1977·Headache·D F Horrobin
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·P H Guth
Apr 1, 1986·Hepato-gastroenterology·S E Miederer
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·E D Jacobson
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Nov 1, 1982·Digestive Diseases and Sciences·S J KonturekA Dembińska-Kieć

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Citations

Dec 12, 1996·European Journal of Pharmacology·S K KaanC H Cho
Jul 15, 1999·Journal of Ethnopharmacology·I B SuffrediniJ A Sertié
Jul 25, 2000·Journal of Ethnopharmacology·O O OkwariM U Eteng
Aug 1, 1997·Alimentary Pharmacology & Therapeutics·J K KoC H Cho
Jan 1, 1994·Journal of Gastroenterology and Hepatology·C H ChoX L Tang
May 16, 2014·Life Sciences·L LuC H Cho
May 15, 2007·Life Sciences·Emily K Y LamC H Cho
Aug 10, 2004·World Journal of Gastroenterology : WJG·Joshua Ka-Shun KoShiu-Kum Lam
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jiing C LuoChi H Cho

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