PMID: 9421196Jan 8, 1998Paper

Endogenous prostaglandins regulate rat renal phospholipid 'de novo' synthesis

Biochimica Et Biophysica Acta
María del Carmen Fernández-ToméNorma B Sterin-Speziale

Abstract

Rat renal papilla is the zone of the kidney enjoying the most active phospholipid metabolism and also the highest prostaglandin production. We studied the phospholipid biosynthesis and the relationship between phospholipid de novo synthesis and prostaglandin biosynthesis in rat renal papilla. Indomethacin inhibited the biosynthesis of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and phosphatidic acid. Exogenous PGF2alpha and PGD2 restored biosynthetic activity in the presence of indomethacin and also increased the activity of the enzymes involved in the Kennedy pathway. The decrease in phospholipid biosynthesis maintained a linear relationship with the decrease in prostaglandin biosynthesis. Moreover, esculetin, which stimulates prostaglandin synthesis, brought about a significant increase in 32P incorporation to the three phospholipids studied. The evidence presented in this paper indicates that renal PGF2alpha and PGD2 modulate phospholipid de novo synthesis in rat renal papilla.

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Citations

Dec 28, 2012·Journal of Lipid Research·Cecilia I CasaliMaría C Fernández Tome
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Jeremy J OliverRoger G Evans
Dec 31, 2003·Biochemical Pharmacology·María Fernández-TomeNorma Sterin-Speziale
Jul 14, 2004·Biochemical and Biophysical Research Communications·María Fernández-TomeNorma Sterin-Speziale

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