Endogenous protein-synthesis efficiency in trauma victims.

Metabolism: Clinical and Experimental
M JeevanandamW R Schiller

Abstract

Hyperglycemia despite increased glucose oxidation and hypoaminoacidemia despite increased rate of protein breakdown are frequently seen in hypermetabolic and highly catabolic patients with major trauma. The extent of reutilization of endogeneously produced amino acids in the synthesis of new proteins (protein recycling) by the traumatized human is poorly understood. The protein synthesis efficiency was measured in ten multiple trauma patients during the early "flow" phase of injury, and these data were compared with normal and depleted patients. In acute trauma the synthetic efficiency of protein is significantly (P = .01) low (61% +/- 4%) compared with other pathologic states (78% +/- 1%). This suggests that the priority is preferentially set to meet the increased demands of glucose production, and a major portion of the amino acids are utilized for purposes other than synthesis of body proteins. This observation should be taken into account in the early management of acute trauma patients before the body adapts to accept the exogenous supply of amino acids.

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Citations

Jun 1, 1992·Arquivos de neuro-psiquiatria·A SchelpR Burini
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·M JeevanandamW R Schiller
Mar 1, 1994·Metabolism: Clinical and Experimental·A TaveroffL J Hoffer

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