Jul 1, 1997

Endogenous retroviral transcripts in myocytes from spontaneously hypertensive rats

Hypertension
G SirokmanO H Bing

Abstract

The spontaneously hypertensive rat (SHR) is a well studied animal model of genetic hypertension and heart disease of unknown cause. With the use of differential display, a transcript was found in SHR myocardium that on sequence analysis was identified as an endogenous retrovirus (ERV). ERV gene expression was greater than an order of magnitude increased in adult SHR hearts relative to age-matched normotensive Wistar-Kyoto rats and was further increased in hearts from SHR with heart failure. In situ hybridization studies demonstrated that increased ERV gene expression was localized to myocardial cells. Increases in ERV transcripts in SHR suggest a possible link between inherited proviral elements and genetic hypertensive heart disease.

  • References12
  • Citations6

References

Mentioned in this Paper

Rats, Inbred SHR
Sequence Determinations, RNA
Transcription, Genetic
Myocardium
Rats, Inbred WKY
Histological Techniques
Hypertensive Disease
Heart
Northern Blot
Autoradiography

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