Endogenous retrovirus HERV-I LTR family in primates: sequences, phylogeny, and evolution

Archives of Virology
J-W Lee, H-S Kim

Abstract

A human endogenous retrovirus (HERV-I; RTVL-I) has been located within the first intron of a haptoglobin-related gene. Two members of the HERV-I family were identified in proximal Yq11.2 and caused AZFa microdeletions as a result of intra-chromosomal recombination events in azoospermic patients. Using PCR25 and the sequencing approach with the genomic DNAs of primates, hominoids, Old and New World monkeys, and prosimians, the HERV-I LTR elements were identified and analysed. The LTR elements were detected only in the hominoids and the Old World monkeys, indicating that the HERV-I LTR elements were inserted into the primate genome after the split of the New World monkeys in the Oligocene era, about 33 million years ago. Nineteen members of the HERV-I LTR elements from the hominoids and the Old World monkeys showed multiple insertions or deletions. They showed a 78.6-97.4% sequence similarity to that of Hu-15 (accession no. AF290422; HERV-I LTR on human Yq11.2). The evolutionary relationships within the HERV-I LTR family among hominoids and Old World monkeys showed a random cluster, indicating that HERV-I LTR elements have evolved independently in primate evolution.

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Citations

Jan 2, 2007·PLoS Genetics·Lucia CarbonePieter J de Jong
May 14, 2008·Placenta·J-W HuhH-S Kim
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Necip PirincciMehmet Aslan
Aug 1, 2013·International Journal of Molecular Medicine·Hong-Lian YuFan Zhu

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