Endogenous rhythms in Period1 mutant suprachiasmatic nuclei in vitro do not represent circadian behavior.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Julie S PendergastShin Yamazaki

Abstract

The mammalian circadian pacemaker in the suprachiasmatic nuclei (SCN) controls daily rhythms of behavior and physiology. Lesions of the SCN cause arrhythmicity of locomotor activity, and transplants of fetal SCN tissue restore rhythmic behavior that is consistent with the periodicity of the donor's genotype, suggesting that the SCN determines the period of the circadian behavioral rhythm. While several studies have demonstrated that the circadian characteristics of in vitro SCN rhythms represent circadian behavior, others have shown that the periods of explanted SCN are not always congruent with locomotor activity. We find that the aberrant rhythms of ex vivo SCN lacking functional Period1 (Per1(-/-)) do not represent the behavioral rhythms of the mutant animals. Surprisingly, in C57BL/6J Per1(-/-) mice, the real-time circadian gene promoter activity rhythm is weak or absent in adult SCN slices in vitro even though the free-running wheel-running activity rhythm is indistinguishable from wild-type (Per1(+/+)) mice. While some neurons in Per1(-/-) SCN explants exhibit robust circadian rhythms, others have irregular and/or low-amplitude rhythms. Together, these data suggest that either a small population of rhythmic neurons in the...Continue Reading

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Citations

Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Julie S PendergastShin Yamazaki
Feb 14, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ryan W LoganDipak K Sarkar
May 17, 2014·PloS One·Christopher M CiarleglioDouglas G McMahon
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julie S PendergastShin Yamazaki
Jun 26, 2013·Scientific Reports·Akiko HidaKazuo Mishima
Jul 29, 2011·Chronobiology International·Julie S Pendergast, Shin Yamazaki
Feb 16, 2010·Current Biology : CB·Shuqun ShiCarl Hirschie Johnson
Sep 10, 2016·Scientific Reports·Hiroyuki TamiyaMasahiro Akishita
Nov 15, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lauren G DoumaMichelle L Gumz
May 25, 2013·Journal of Applied Physiology·Gretchen WolffKaryn A Esser
Jul 5, 2013·Proceedings. Biological Sciences·Guy BlochWilliam J Schwartz
Aug 9, 2011·Essays in Biochemistry·Christian BeauléErik D Herzog
Oct 16, 2016·The European Journal of Neuroscience·Malini RiddleRae Silver
Mar 9, 2021·PLoS Computational Biology·Koichiro Uriu, Hajime Tei

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