Endogenous testosterone levels are associated with neural activity in men with schizophrenia during facial emotion processing

Behavioural Brain Research
Ellen JiThomas W Weickert

Abstract

Growing evidence suggests that testosterone may play a role in the pathophysiology of schizophrenia given that testosterone has been linked to cognition and negative symptoms in schizophrenia. Here, we determine the extent to which serum testosterone levels are related to neural activity in affective processing circuitry in men with schizophrenia. Functional magnetic resonance imaging was used to measure blood-oxygen-level-dependent signal changes as 32 healthy controls and 26 people with schizophrenia performed a facial emotion identification task. Whole brain analyses were performed to determine regions of differential activity between groups during processing of angry versus non-threatening faces. A follow-up ROI analysis using a regression model in a subset of 16 healthy men and 16 men with schizophrenia was used to determine the extent to which serum testosterone levels were related to neural activity. Healthy controls displayed significantly greater activation than people with schizophrenia in the left inferior frontal gyrus (IFG). There was no significant difference in circulating testosterone levels between healthy men and men with schizophrenia. Regression analyses between activation in the IFG and circulating testoste...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1994·Psychoneuroendocrinology·R D Oades, R Schepker
Aug 27, 1998·Schizophrenia Bulletin·M K MandalA B Prasad
Oct 31, 1998·Psychiatry Research·G H IhnenJ Martin
May 9, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y Kaneda, A Fujii
Oct 25, 2000·Neuroscience Letters·S BeyenburgB Stoffel-Wagner
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study of Aging
Apr 11, 2001·Schizophrenia Research·J EdwardsR J Wales
Nov 27, 2002·The American Journal of Psychiatry·Raquel E GurRuben C Gur
Sep 30, 2003·The American Journal of Psychiatry·Christian G KohlerRuben C Gur
Jun 1, 2004·The American Journal of Psychiatry·J Daniel RaglandRaquel E Gur
Apr 6, 2005·Archives of General Psychiatry·Andreas S Meyer-LindenbergKaren Faith Berman
May 1, 2008·Journal of Neuroendocrinology·D MontagueD R Rubinow
Jan 13, 2009·Psychoneuroendocrinology·Birgit DerntlUte Habel
Mar 31, 2009·Schizophrenia Bulletin·Christian G KohlerPaul J Moberg
Apr 8, 2009·Neuroscience Letters·P Fusar-PoliP L Politi
Oct 15, 2010·Journal of Psychopharmacology·Andrew J Bradley, Timothy G Dinan
Mar 16, 2013·Psychoneuroendocrinology·L MooreT W Weickert

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Citations

Aug 8, 2015·The Journal of Nervous and Mental Disease·Yuqing SongCharles Zaroff
Jul 6, 2019·Current Protein & Peptide Science·Daniela JezovaNatasa Hlavacova
Oct 28, 2019·Nordic Journal of Psychiatry·Mirna Sisek-ŠpremMiroslav Herceg
Sep 25, 2017·Journal of Neuroendocrinology·S J OwensC Shannon Weickert
Jul 14, 2017·Archives of Women's Mental Health·Alexandre González-RodríguezRosa Catalán
Nov 8, 2020·Journal of Molecular Neuroscience : MN·Wei HuangYong Cheng
May 31, 2021·Neuroscience and Biobehavioral Reviews·Pengfei XuGaolang Gong

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