Endogenous thrombopoietin levels and effect of recombinant human thrombopoietin on megakaryocyte precursors in term and preterm babies

Pediatric Research
N A MurrayI A Roberts

Abstract

Thrombocytopenia (platelets <150 x 10[9]/L) is common in the early newborn period. Recent evidence suggests this is due mainly to impaired fetal megakaryocytopoiesis/platelet production. The cause remains unknown. Thrombopoietin (Tpo) is now recognized as the major regulator of platelet production in adults. However, nothing is known about Tpo levels, or the role of Tpo in megakaryocytopoiesis/platelet production, in the fetus/newborn. To answer these questions we: 1) measured plasma Tpo levels by ELISA at birth in healthy term (n = 17) and preterm (gestational age, 24-34 wk) babies (n = 16), and in thrombocytopenic preterm babies (n = 13); and 2) assessed the in vitro Tpo dose response characteristics of circulating megakaryocyte precursor cells (MKp) from all three groups. The median Tpo levels were similar in term babies 145 pg/mL (range 52-237 pg/mL) compared with preterm babies 132 pg/mL (32-318 pg/mL). In the thrombocytopenic preterm babies the median Tpo level of 185 (46-264) was not significantly higher than in healthy babies, despite the fact that their median platelet counts were significantly lower--82 x 10(9)/L (range 21-135), compared with the healthy preterm babies 252 x 109/L (152-320)--p < 0.0001. Tpo levels in ...Continue Reading

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Citations

Aug 26, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·I Roberts, N A Murray
Nov 16, 2013·Experimental & Molecular Medicine·Michael R Copley, Connie J Eaves
May 5, 1999·Current Opinion in Hematology·G Rondini, G Chirico
Apr 25, 2002·Journal of Pediatric Hematology/oncology·David A PaulSteven McKenzie
Apr 18, 2001·Journal of Pediatric Hematology/oncology·M C SolaR D Christensen
Dec 13, 2002·Acta Paediatrica. Supplement·N A Murray
Jun 17, 2008·Pediatric Research·Rachel E BrownMartha C Sola-Visner
May 27, 2017·Platelets·Katherine A SpargerMartha C Sola-Visner
Feb 15, 2001·Current Opinion in Pediatrics·I A Roberts, N A Murray
Jan 25, 2003·Current Opinion in Pediatrics·Irene A G Roberts, Neil A Murray
Apr 7, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kousaku MatsubaraHiroshi Miyazaki
Apr 23, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·H SallmonM C Sola-Visner
Feb 16, 2000·Pediatric Research·S J Israels
Jan 14, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hideki NakayamaToshiro Hara
Oct 21, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Pamela J Kling, John J Hutter
Feb 15, 2002·International Journal of Hematology·Kousaku MatsubaraHiroshi Miyazaki
Aug 14, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·K MatsubaraT Fukaya
Apr 9, 2005·British Journal of Haematology·Christof Dame, Anton Heinz Sutor
Jul 9, 2011·Current Opinion in Hematology·Zhi-Jian Liu, Martha Sola-Visner
Jan 7, 2021·British Journal of Haematology·Satoru TakeshitaMineyoshi Aoyama
Dec 13, 2002·Acta Paediatrica. Supplement·M C Sola, L M Rimsza
Sep 15, 2000·Clinics in Perinatology·M C SolaL M Rimsza
Aug 30, 2011·Seminars in Fetal & Neonatal Medicine·Paul Monagle, Patricia Massicotte

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