PMID: 148969May 1, 1978Paper

Endogenous thymic factors regulating cell proliferation and analysis of their mechanism of action

Cell and Tissue Kinetics
I Blazsek, D Gaál

Abstract

Endogenous factors inhibiting the proliferation of T-lymphocytes were investigated which may function as modulators of T-lymphocyte production within the thymus. An extract from calf thymus (T4) enriched in lymphocyte chalone arrests rat thymocytes at the G1 leads to S boundary and in the S phase of the cell cycle in short-term cultures. It also inhibits the proliferative response of human peripheral blood lymphocytes to PHA-P in a time-dependent manner, as well as the spontaneous proliferation of in vitro cultured human chronic leukaemic lymphoblasts. This crude extract contains two active moities which can be isolated by molecular filtration on Sephadex G-75 column. A species non-specific, cell line selectivity inhibitory effect is characteristic of the high molecular weight fraction (mol. wt. greater than 40,000). This activity is resistant to moderate heat treatment and trypsin but is sensitive to mild alkaline hydrolysis and to RNase A digestion. About ten protein components and a toluidine blue positive substance can be detected by analytical polyacrylamide gel electrophoresis. The active inhibitor, a proposed protein-RNA complex, might be identical with the chalone. The low molecular weight, non-dialysable factor (T4-4) ...Continue Reading

References

Feb 1, 1975·Biological Reviews of the Cambridge Philosophical Society·W S Bullough
Jan 1, 1975·International Review of Cytology·B B LozzioS V Lair
Jan 1, 1976·Mechanisms of Ageing and Development·I BlazsekL Holczinger
Feb 28, 1975·Annals of the New York Academy of Sciences·J A HooperA L Goldstein
Aug 1, 1975·Cell·D H Schlesinger, G Goldstein
Jul 1, 1975·Experimental Cell Research·T AoyamaK Nishiguchi
Jan 1, 1974·Analytical Biochemistry·S C ChouK A Conklin
Sep 17, 1971·Science·J C HouckS Leikin
Aug 1, 1962·Biological Reviews of the Cambridge Philosophical Society·W S BULLOUGH
Jul 2, 1965·Science·A SZENT-GYOERGYI

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Citations

Sep 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·E I BueverovaD Gefeni
Jan 1, 1986·Comparative Immunology, Microbiology and Infectious Diseases·G MathéJ L Misset
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maribel JaimeOriol Bachs
Oct 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A Balázs, K Barabás
Dec 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·E SundrehagenI Strøm-Gundersen
Jan 1, 1987·Cell and Tissue Kinetics·H B BenestadE M Siebke
Sep 1, 1985·Cell and Tissue Kinetics·M SorianoO Bachs

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