Abstract
Melioidosis is a frequent cause of severe sepsis in Southeast Asia caused by the gram-negative bacterium Burkholderia pseudomallei. Patients with melioidosis have elevated circulating levels of tissue-type plasminogen activator, an important regulator of fibrinolysis. In this study, we aimed to investigate the role of tissue-type plasminogen activator during melioidosis. Animal study. University research laboratory. Wild-type and tissue-type plasminogen activator-deficient C57BL/6 mice. Mice were intranasally infected with viable Burkholderia pseudomallei and killed after 24, 48, or 72 hrs for harvesting of lungs, liver, and blood. Additionally, survival studies were performed. Experimentally induced melioidosis was associated with elevated levels of tissue-type plasminogen activator in lungs of infected wild-type mice. During infection with Burkholderia pseudomallei, tissue-type plasminogen activator-deficient mice were protected when compared to wild-type mice as demonstrated by a strongly decreased mortality (62% vs. 100% amongst wild-type mice, p < .0001), together with decreased pulmonary bacterial loads, less severe histopathological scores, and decreased fibrinolysis. These results were accompanied with an early increase...Continue Reading
References
Jun 22, 1999·Infection and Immunity·P SantanirandG J Bancroft
Nov 24, 1999·The Journal of Infectious Diseases·F N LauwT van der Poll
Feb 11, 2000·The Journal of Infectious Diseases·A J SimpsonJ M Prins
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita W RijneveldTom van Der Poll
Feb 5, 2004·Thorax·M J SchultzT van der Poll
Nov 2, 2004·The European Respiratory Journal·G ChoiT van der Poll
Dec 23, 2004·Shock·Toshiaki IbaHisaaki Kato
Apr 16, 2005·Clinical Microbiology Reviews·Allen C Cheng, Bart J Currie
Jul 15, 2005·Blood·Sebastiaan WeijerTom van der Poll
Mar 17, 2006·Nature Reviews. Microbiology·W Joost WiersingaSharon J Peacock
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosemarijn RenckensTom van der Poll
May 23, 2007·Infection and Immunity·W Joost WiersingaTom van der Poll
Aug 7, 2007·PLoS Medicine·W Joost WiersingaTom van der Poll
Sep 13, 2007·Thrombosis and Haemostasis·Simone Bergmann, Sven Hammerschmidt
Jan 16, 2008·Journal of Thrombosis and Haemostasis : JTH·R RenckensT van der Poll
Oct 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joris J T H RoelofsSandrine Florquin
Oct 16, 2008·The Journal of Infectious Diseases·W Joost WiersingaTom van der Poll
Oct 31, 2008·Trends in Neurosciences·Manuel YepesDenis Vivien
Nov 19, 2008·Infection and Immunity·Ann CraigSamithamby Jeyaseelan
Dec 6, 2008·Blood·Hongmin SunDavid Ginsburg
Dec 31, 2008·Critical Care Medicine·Jacobien J HoogerwerfTom van der Poll
Jan 30, 2010·Critical Care Medicine·Marcel Levi, Tom van der Poll
Dec 15, 2010·PLoS Neglected Tropical Diseases·Bart J CurrieAllen C Cheng
Aug 19, 2011·Journal of Thrombosis and Haemostasis : JTH·L M KagerT van der Poll
Nov 8, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ella M MeumannBart J Currie
Citations
Jul 23, 2013·PLoS Neglected Tropical Diseases·Liesbeth M KagerTom van der Poll
Apr 26, 2014·PLoS Neglected Tropical Diseases·Liesbeth M KagerTom van der Poll
Sep 3, 2013·American Journal of Respiratory and Critical Care Medicine·Liesbeth M KagerTom van der Poll
Oct 21, 2015·Critical Reviews in Microbiology·Marijke PeetermansPeter Verhamme
Nov 18, 2015·Thrombosis Research·Lionel LattenistJoris J T H Roelofs
Apr 4, 2014·Thrombosis and Haemostasis·Tom van der Poll, Heiko Herwald
Dec 12, 2012·Journal of Thrombosis and Haemostasis : JTH·L M KagerT van der Poll
May 7, 2015·BMC Medicine·Maiara Marx Luz FiusaErich V De Paula
Apr 4, 2019·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Zenith KhashimDavid F Kallmes
Jun 20, 2012·Critical Care Medicine·Perenlei Enkhbaatar, Daniel L Traber
Jul 28, 2013·Critical Care Medicine·Liesbeth M KagerTom Van der Poll
Sep 26, 2013·Critical Care Medicine·Perenlei Enkhbaatar
Jan 9, 2014·Critical Care Medicine·Liesbeth M KagerTom van der Poll
Jan 1, 2020·PloS One·Yzabella Alves Campos NogueiraErich Vinicius De Paula
Jun 26, 2014·Expert Review of Anti-infective Therapy·Liesbeth Martine KagerWillem Joost Wiersinga