PMID: 8993365Oct 25, 1996Paper

Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides

Annals of the New York Academy of Sciences
R I Lehrer, T Ganz

Abstract

Although newly recognized, endogenous cystine-stabilized beta-sheet antimicrobial peptides have ancient origins. These peptides can arm circulating phagocytes and cells of the gastrointestinal, respiratory, and genitourinary tracts to resist invasion by bacteria, mycobacteria, fungi, and enveloped viruses. Defensins and protegrin-like peptides are likely to play a considerable role in innate immunity and may provide molecular templates that can be used to generate novel antibiotics for topical and systemic use.

References

Dec 15, 1992·Biochemical and Biophysical Research Communications·M MasudaT Murakami
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B L KaganR I Lehrer
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M LeippeH J Müller-Eberhard
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G DiamondC L Bevins
Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
Oct 1, 1985·The Journal of Clinical Investigation·M E SelstedR I Lehrer
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·G H GudmundssonH G Boman
Jul 17, 1995·FEBS Letters·C ZhaoR I Lehrer
Jul 17, 1995·FEBS Letters·K W BenschW G Forssmann
May 1, 1995·Pharmacology & Therapeutics·T Ganz, R I Lehrer
May 1, 1995·The Plant Cell·F R TerrasJ Vanderleyden
Mar 17, 1995·Science·B S SchonwetterM A Zasloff
Nov 1, 1994·Journal of Leukocyte Biology·E W EvansB G Harmon
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·M LeippeH J Müller-Eberhard
Apr 11, 1994·FEBS Letters·S S HarwigR I Lehrer
Apr 15, 1994·Annals of the New York Academy of Sciences·S IwanagaS Kawabata
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G DiamondC L Bevins
Jan 1, 1995·Advances in Experimental Medicine and Biology·S S HarwigR I Lehrer
May 1, 1995·Journal of Peptide Science : an Official Publication of the European Peptide Society·S S HarwigR I Lehrer

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Citations

Mar 22, 2000·The Journal of Cell Biology·Y S López-BoadoW C Parks
Jul 25, 2000·The Journal of Biological Chemistry·D M HooverJ Lubkowski
Mar 30, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·T LejonJ S Svendsen
Aug 4, 2001·The Journal of Biological Chemistry·D M HooverJ Lubkowski
Jul 11, 2001·Critical Care Medicine·L SteinstraesserS C Wang
Oct 16, 2002·The Journal of Biological Chemistry·Joanna K DaviesDavid C Wilton
Feb 12, 2004·Oral Microbiology and Immunology·P PremratanachaiJ M Guthmiller
Feb 11, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Henrietta SzappanosLászló Csernoch
Jun 10, 2005·Journal of Leukocyte Biology·Mikkel FaurschouNiels Borregaard
May 20, 1999·Biopolymers·D Andreu, L Rivas
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gregorino PaoneJoel Moss
Jun 19, 2001·Biological Chemistry·W van 't HofA V Amerongen
Mar 5, 2003·Pharmacological Reviews·Michael R Yeaman, Nannette Y Yount
Dec 10, 2002·Hybridoma and Hybridomics·Shigeharu KurosawaHiroshige Sasahara
May 20, 1999·Biopolymers·J L DimarcqJ Hoffmann
May 23, 2002·Antimicrobial Agents and Chemotherapy·Lars SteinstraesserStewart C Wang
Oct 4, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Andrès
Sep 29, 2012·Zoological Research·Hui-Juan GuangHai-Ning Yu
Jul 15, 2015·Probiotics and Antimicrobial Proteins·Preeti ChaturvediAmit Pande
Feb 16, 2000·Journal of Peptide Science : an Official Publication of the European Peptide Society·N F DawsonJ D Wade
May 10, 2002·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Yutaka HirakuraBruce L Kagan
Mar 14, 2009·Applied Biochemistry and Biotechnology·Yueling WangMingyuan Li
Mar 23, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·L SteinsträsserH U Steinau
Apr 19, 2012·The Journal of Biological Chemistry·Fung T LayMark D Hulett
Mar 29, 2003·The Journal of Peptide Research : Official Journal of the American Peptide Society·C Chong-CerrilloL M de la Maza
Mar 7, 2006·Critical Reviews in Clinical Laboratory Sciences·Annukka Paju, Ulf-Håkan Stenman
Aug 19, 2004·Journal of Leukocyte Biology·Andreas SchaffnerDonald G Guiney
Aug 30, 2000·European Journal of Clinical Investigation·M FryeR Gropp
Sep 22, 2012·Biochemical and Biophysical Research Communications·Björn SpudySascha Jung
Aug 12, 1999·Biologicals : Journal of the International Association of Biological Standardization·A R NeurathS Jiang

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