Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation.

Cell and Tissue Research
Dany Spencer Adams, Michael Levin

Abstract

Alongside the well-known chemical modes of cell-cell communication, we find an important and powerful system of bioelectrical signaling: changes in the resting voltage potential (Vmem) of the plasma membrane driven by ion channels, pumps and gap junctions. Slow Vmem changes in all cells serve as a highly conserved, information-bearing pathway that regulates cell proliferation, migration and differentiation. In embryonic and regenerative pattern formation and in the disorganization of neoplasia, bioelectrical cues serve as mediators of large-scale anatomical polarity, organ identity and positional information. Recent developments have resulted in tools that enable a high-resolution analysis of these biophysical signals and their linkage with upstream and downstream canonical genetic pathways. Here, we provide an overview for the study of bioelectric signaling, focusing on state-of-the-art approaches that use molecular physiology and developmental genetics to probe the roles of bioelectric events functionally. We highlight the logic, strategies and well-developed technologies that any group of researchers can employ to identify and dissect ionic signaling components in their own work and thus to help crack the bioelectric code. T...Continue Reading

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Citations

Feb 26, 2013·Cell and Tissue Research·Hans-Hermann Gerdes, Rainer Pepperkok
Jul 12, 2014·Annual Review of Biomedical Engineering·Deanna M ThompsonChristine E Schmidt
Nov 17, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·G Pezzulo, M Levin
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Jul 21, 2020·Bioelectricity·Vaibhav P Pai, Dany Spencer Adams

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