Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jianmin ChenAmrita Ahluwalia

Abstract

The severity of cardiac dysfunction predicts mortality in sepsis. Activation of transient receptor potential vanilloid receptor type (TRPV)-1, a predominantly neuronal nonselective cation channel, has been shown to improve outcome in sepsis and endotoxemia. However, the role of TRPV1 and the identity of its endogenous ligands in the cardiac dysfunction caused by sepsis and endotoxemia are unknown. Using TRPV1-/- and TRPV1+/+ mice, we showed that endogenous activation of cardiac TRPV1 during sepsis is key to limiting the ensuing cardiac dysfunction. Use of liquid chromatography-tandem mass spectrometry lipid analysis and selective inhibitors of arachidonic metabolism suggest that the arachidonate-derived TRPV1 activator, 20-hydroxyeicosateraenoic acid (20-HETE), underlies a substantial component of TRPV1-mediated cardioprotection in sepsis. Moreover, using selective antagonists for neuropeptide receptors, we show that this effect of TRPV1 relates to the activity of neuronally released cardiac calcitonin gene-related peptide (CGRP) and that, accordingly, administration of CGRP can rescue cardiac dysfunction in severe endotoxemia. In sum activation of TRPV1 by 20-HETE leads to the release of CGRP, which protects the heart against ...Continue Reading

References

Apr 1, 1991·Journal of Medicinal Chemistry·H ChoT Ishihara
Apr 1, 1984·Annals of Internal Medicine·M M ParkerJ E Parrillo
Nov 21, 1998·Critical Care Medicine·B MuntM Tweeddale
Nov 7, 1999·Intensive Care Medicine·C J FernandesE Knobel
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·S W HwangU Oh
Apr 3, 2001·Annual Review of Neuroscience·M J Caterina, D Julius
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 12, 2003·Journal of the American College of Cardiology·Peter AmmannThomas Fehr
Jul 31, 2003·The Journal of Surgical Research·Patrick BryantRobert N Cooney
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gautam BhaveRobert W Gereau
Jul 9, 2004·Annals of the New York Academy of Sciences·Barry B KaplanAnthony E Gioio
Aug 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Judith A EnyeartJohn J Enyeart
Oct 27, 2004·Anesthesia and Analgesia·Semra DemirbilekMehmet Bayraktar
Feb 18, 2005·Acta Pharmacologica Sinica·Donna H Wang
Apr 21, 2005·Journal of Dental Research·D-B ShiehS-N Wu
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Padmam PuneetMadhav Bhatia
May 6, 2006·Thrombosis and Haemostasis·Naoaki HaradaNaomi Nakagata
Jan 24, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zsuzsanna HelyesJános Szolcsányi
May 2, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alison SextonAmrita Ahluwalia
Jun 22, 2007·Critical Care Medicine·Henry E WangDonald M Yealy
Jul 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natalie ClarkSusan D Brain
Aug 19, 2007·Circulation·M W Merx, C Weber
Mar 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Youping WangDonna H Wang
Dec 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Jesús BlancoUNKNOWN Grupo de Estudios y Análisis en Cuidados Intensivos
Apr 18, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Zhonghai WeiLiangrong Zheng
May 19, 2009·European Journal of Pharmacology·Benedicte Y De WinterPaul A Pelckmans
Sep 17, 2009·Apoptosis : an International Journal on Programmed Cell Death·Jun-Qiu SongYong-Fen Qi
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Aug 10, 2010·The Journal of Physiology·Milena Studer, Peter A McNaughton

❮ Previous
Next ❯

Citations

Jan 7, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Michele G Padovan, Lucy V Norling
Jul 8, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qadeer AzizAndrew Tinker
Nov 5, 2019·Frontiers in Oncology·Joanna Katarzyna BujakPiotr Bednarczyk
Sep 29, 2020·Frontiers in Immunology·Jianmin ChenChristoph Thiemermann
Jun 27, 2020·International Journal of Molecular Sciences·Tamara SzabadosPéter Bencsik
Oct 30, 2020·Frontiers in Immunology·Johann VolzkeUNKNOWN KoInfekt Study Group
Apr 9, 2021·Biochemistry. Biokhimii︠a︡·Irina N GladkikhSergey A Kozlov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Hiroshi Takami
Revue du rhumatisme : maladies des os et des articulations
M S Moukhtar, A Jullienne
Nihon rinsho. Japanese journal of clinical medicine
Yoshifumi Ikeda, Hiroshi Takami
Nihon rinsho. Japanese journal of clinical medicine
Y Ikeda, Hiroshi Takami
© 2022 Meta ULC. All rights reserved