Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis?

The Journal of Infectious Diseases
Anelia DietmannErich Schmutzhard

Abstract

Molecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria-specifically, cerebral malaria-are still unclear. Transforming growth factor beta (TGF-beta) family members are important regulators of inflammation that influence malaria pathogenesis. The soluble form of the auxiliary receptor endoglin (sEng) may play a role in malaria pathogenesis. Serum levels of sEng were measured using enzyme-linked immunosorbent-assay in Gabonese children with cerebral malaria (n = 7) severe malaria (n = 43), or uncomplicated malaria (n = 43) and were compared with levels in healthy control subjects (n = 25) and in another infectious disease group (n = 8). Serum sEng levels were higher in patients with cerebral malaria and all patients with severe malaria when compared with levels in patients in the other infection group and the healthy control group. Furthermore, sEng correlated significantly with disease severity. Only 7% of patients with uncomplicated malaria and none of the control patients (patients in the other infection group or the healthy control group) had serum levels higher than 12 ng/mL, whereas this was found in 85.7% of patients with cerebral malaria and 46.5% of patients with severe malaria. High sEn...Continue Reading

Citations

Jun 15, 2010·Malaria Journal·Joachim SchmutzhardErich Schmutzhard
Nov 24, 2011·International Journal of Biological Sciences·Douglas J PerkinsJohn Michael Ong'echa
Jun 6, 2013·Biomarkers in Medicine·Laurens Manning, Timothy Mark Earls Davis
Jan 22, 2014·BMC Infectious Diseases·Andrea L ConroyKevin C Kain
Aug 11, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Andrea L ConroyKevin C Kain
Jun 15, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cornelia A M van de WegByron E E Martina
Jan 31, 2018·Clinical and Experimental Hypertension : CHE·Olive P KhaliqIrene Mackraj
Jul 9, 2010·Current Opinion in Infectious Diseases·Danny A Milner
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Claudia Lucía FigueroaJürg Niederbacher
Jul 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·José M López-Novoa, Carmelo Bernabeu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

The Journal of Infectious Diseases
Nicholas A V BeareMalcolm E Molyneux
Nature Medicine
Shivalingappa VenkateshaS Ananth Karumanchi
Proceedings of the National Academy of Sciences of the United States of America
Atis MuehlenbachsPatrick E Duffy
Proceedings of the National Academy of Sciences of the United States of America
Tsin W YeoNicholas M Anstey
© 2022 Meta ULC. All rights reserved