Endoluminal gastroplication for treatment of patients with classic gastroesophageal reflux symptoms and borderline 24-h pH studies

Scandinavian Journal of Gastroenterology
J J LiuJohn R Saltzman

Abstract

Patients with classic gastroesophageal reflux disease (GERD) symptoms and borderline 24-h pH studies are not considered to be good candidates for surgical fundoplication. Endoluminal gastroplication (ELGP) is a new endoscopic treatment for patients with GERD. The aim of this study was to evaluate the efficacy of ELGP in these patients. Patients with heartburn, regurgitation symptoms and a DeMeester score of less than 30 were studied. ELGP involved placement of two or three plications within 2 cm of the gastroesophageal junction. Clinical outcomes measured were heartburn symptom score (HSS), regurgitation frequency score (RFS) and medication use. Twenty-five patients (11 M, 14 F, mean age of 51 years) had a medication use of 11.5 doses of proton-pump inhibitors per week prior to ELGP. Average lower esophageal sphincter pressure measured 15 +/- 8 mmHg, and average DeMeester score was 18 +/- 8. Nine patients had hiatal hernias and 11 had esophagitis. Twenty-four patients were available for a mean follow-up of 12 months. HSS significantly decreased from 48 to 17 (P < 0.01) and RFS was reduced from 1.8 to 0.7 (P < 0.01). Proton-pump inhibitor use was 5.3 doses per week (P < 0.01) post-ELGP; 12 patients (50%) were off medications, 3 ...Continue Reading

References

Dec 1, 1969·The British Journal of Surgery·J Spencer
Aug 1, 1996·Alimentary Pharmacology & Therapeutics·C M BateP D Richardson
Sep 11, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·G M CamposC G Bremner
May 2, 2002·Gastroenterology·Robert S SandlerRobert Rubin

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Citations

Jul 2, 2005·Gastrointestinal Endoscopy·Yang K Chen
Jun 14, 2006·American Journal of Surgery·Atul K MadanDavid S Tichansky
Dec 3, 2014·Gastrointestinal Endoscopy·Nathan E Conway, Lee L Swanström
Aug 18, 2005·Thoracic Surgery Clinics·Mumnoon HaiderCharles J Filipi
Mar 18, 2006·The American Journal of Gastroenterology·Julia J LiuJohn R Saltzman
Jul 16, 2008·Current Gastroenterology Reports·Marvin Ryou, Christopher C Thompson
Nov 14, 2007·European Journal of Gastroenterology & Hepatology·Lucía C FryPeter Malfertheiner
May 12, 2009·Surgical Endoscopy·Yashodhan S KhajancheeLee L Swanstrom
Mar 21, 2009·European Journal of Gastroenterology & Hepatology·Alexander J EckardtThomas Rösch
Sep 15, 2009·Drugs·Julia J Liu, John R Saltzman
Aug 12, 2005·Current Opinion in Gastroenterology·Yang K Chen
Aug 31, 2006·Digestion·Spiros N Sgouros, Christina Bergele
Dec 28, 2006·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Michele MarcheseGuido Costamagna

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