Endoluminal high-dose-rate brachytherapy for locally recurrent or persistent esophageal cancer

Brachytherapy
Amandeep S TaggarAbraham J Wu

Abstract

Management of locally recurrent or persistent esophageal cancer (EC) after standard chemoradiation is challenging. This study updates our experience of treating medically inoperable EC patients with endoluminal high-dose-rate brachytherapy (EHDRBT) including the patients treated with a novel multiballoon channel centering esophageal applicator. Thirty-three consecutive patients with early-stage primary (n = 7), posttreatment persistent (n = 7), and recurrent (n = 19) EC treated with EHDRBT at our institution were included. Median dose and treatment lengths were 14 Gy (range 10-17.5 Gy) and 6 cm (3.5-9.0 cm), respectively. Endoscopy and biopsy were performed 3 months after EHDRBT and then every 3-6 months thereafter. Median followup was 17.4 months (range 5.0-88.3). Grade 1 and 2 toxicities were observed in 13 (44.8%) and 11 (37.9%) patients, respectively. Grade 3 toxicity (tracheoesophageal fistula) was observed in 1 patient who had previously received two courses of external beam radiotherapy as well as a stent insertion. Median overall survival (OS) for entire cohort was 20.9 months, and 1-year OS was 78%. Complete response was achieved in 58.6% of patients with median time to failure and 1-year disease-free survival of 10.3 ...Continue Reading

Citations

Jan 4, 2021·Radiation and Environmental Biophysics·S Farhad MasoudiFatemeh S Rasouli
Mar 8, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Cristina M DeCesarisJason K Molitoris
Dec 29, 2020·Brachytherapy·Michael R FolkertRanjan Kumar Sur

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