Endoluminal norepinephrine inhibits smooth muscle activity of the pig pyeloureter by stimulation of beta-adrenoceptors without side effects

Basic & Clinical Pharmacology & Toxicology
Jens MortensenFrederik Andreasen

Abstract

It has been demonstrated in pigs that endoluminal administration of norepinephrine reduces the increase in renal pelvic pressure during perfusion. The purposes were to describe concentration-response relationship and receptor mechanism of the effect of norepinephrine on muscle function of pyeloureter and to reveal possible side effects on cardiovascular and renal functions. Renal pelvis was perfused, while pelvic pressure, cardiovascular and renal functional parameters were recorded. In group A, a pelvic pressure increase was examined during pressure flow studies with norepinephrine solutions (0, 1, 5, 50 and 100 microg/ml). In group B, pelvis was perfused with 6 ml/min. norepinephrine solutions (0, 0.001, 0.01, 0.1 and 1 microg/ml). In group C, pelvis was perfused with 6 ml/min. norepinephrine, norepinephrine + sotalol 10(-) (6) mol/l and norepinephrine + phentolamine 10(-) (6) mol/l. Norepinephrine solutions of 0, 10(-) (8), 10(-) (7), 10(-) (6), 10(-) (5) and 10(-) (4) mol/l were used. In group A, all norepinephrine solutions lowered the pelvic pressure increase significantly. Large increases in plasma and urine norepinephrine occurred with 50 and 100 microg/ml, but cardiovascular and renal functions remained unchanged. In g...Continue Reading

References

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Citations

Jun 9, 2009·Interdisciplinary Perspectives on Infectious Diseases·Ashwin DixitSalman T Qureshi
Jun 20, 2018·World Journal of Urology·Theodoros TokasUNKNOWN Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group

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