Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat

The Journal of Veterinary Medical Science
Masashi KawashimaMakoto Shibutani

Abstract

An 11-year-old female goat had invasive and metastatic endometrial adenocarcinoma in the uterus. There was a notable proliferation of endometrial epithelial cells in a tubular growth pattern, with a desmoplastic response. The endometrial epithelial tumor cells metastasized to the kidney, liver and lung. In contrast to the primary and metastatic tumor cells, pleomorphic tumor cells with a choriocarcinoma-like growth pattern infiltrated the mesometrium. Cell proliferation activity was high in both types of tumor cells. Both types of tumor cells expressed cytokeratins AE1/AE3, 7 and CAM5.2; choriocarcinomatous cells also had positive immunoreactions to human chorionic gonadotropin, human placental alkaline phosphatase and α-inhibin. The present case was diagnosed as endometrial adenocarcinoma with choriocarcinomatous differentiation.

References

Apr 1, 1988·Nihon juigaku zasshi. The Japanese journal of veterinary science·K Kadota, M Watanabe
Apr 29, 1967·The Veterinary Record·S Terlecki, W A Watson
Mar 9, 2005·Veterinary Pathology·A M F GiustiM L Carcangiu
Mar 12, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas M Ulbright
Jul 17, 2007·Annals of Diagnostic Pathology·Lars-Christian HornJens Einenkel
Jan 15, 2008·Veterinary Pathology·M Kaufmann-Bart, I Fischer
Dec 20, 2013·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Akihiro HirataTokuma Yanai

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