PMID: 11337092May 5, 2001Paper

Endometrial and myometrial corticotropin-releasing hormone (CRH): its regulation and possible roles

Peptides
A GravanisA N Margioris

Abstract

In human endometrium, both epithelial and stroma cells produce corticotropin-releasing hormone (CRH). Both types of cells also possess specific CRH-binding sites indicating a local effect of endometrial CRH. The transcription of the CRH gene in human endometrium is under the control of steroid hormones and locally produced prostanoids and interleukins. Endometrial CRH interacts with locally produced prostaglandins and interleukins. Based on these observations it can be hypothesized that CRH, prostaglandins and interleukins form a network responsible for the communication between epithelial and stromal cells, at the level of the endometrium, and between endometrial and myometrial cells at the level of uterus. The net product of these interaction is the micro-regulation of the decidualizing process and the preparation of endometrium for the implantation/nidation of the conceptus. Indeed, this network may represent the core of the intrauterine neuroendocrine-immune interactions involved in the decidualization of stroma and implantation of blastocyst. In addition, this network appears to be essential for the fine-tuning of myometrial tone.

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Citations

Jun 17, 2008·Human Reproduction Update·Anthony E Michael, Aris T Papageorghiou
Oct 13, 2004·Peptides·Pasquale FlorioFelice Petraglia
Mar 4, 2015·Neuroscience Bulletin·Phillipe Leff GelmanJuan Pablo Reyes Grajeda
Feb 1, 2019·Birth Defects Research·Lucas Sagrillo-FagundesCathy Vaillancourt
Jul 16, 2010·Endocrine Reviews·Felice PetragliaJohn R G Challis
Oct 19, 2007·Critical Reviews in Clinical Laboratory Sciences·Sophia N KalantaridouAntonis Makrigiannakis
May 1, 2008·Expert Review of Endocrinology & Metabolism·Antonis Makrigiannakis, Achille Gravanis

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