Endometrial assessment in women using tibolone or placebo: 1-year randomized trial and 2-year observational study

Menopause : the Journal of the North American Menopause Society
Maria Celeste Osório WenderPoli Mara Spritzer

Abstract

To assess the effects of tibolone on the endometrium of postmenopausal women. A 1-year randomized, double-blind, placebo-controlled clinical trial and a 2-year open clinical trial. The placebo-controlled trial included 40 participants: 20 in the placebo group and 20 in the tibolone group; in the open trial, 17 participants receiving tibolone were assessed over 24 months. Transvaginal ultrasonography was carried out to assess endometrial thickness, and endometrial appearance was assessed on hysteroscopy. In addition, endometrial samples were submitted to histological examination. The occurrence of uterine bleeding and other adverse effects was also assessed. Results suggest that tibolone does not exert a stimulatory effect on the endometrium: unaltered endometrial thickness, atrophic appearance of most endometria on hysteroscopy, and endometrial histology classified as atrophic, hypotrophic with incipient secretion, or hypotrophic with weak proliferation (one case). Tibolone was effective in the treatment of climacteric symptoms, and only 8.7% of the participants presented uterine bleeding during treatment. Tibolone seems to be an effective option for the treatment of climacteric symptoms in postmenopausal women, especially in w...Continue Reading

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Citations

Sep 23, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Fan QuHefeng Huang
May 7, 2010·Climacteric : the Journal of the International Menopause Society·K-E HuangUNKNOWN Asia Pacific Tibolone Consensus Group
Apr 25, 2007·Climacteric : the Journal of the International Menopause Society·S SharmaI Richmond
Feb 6, 2009·Maturitas·Carolina Sales VieiraRui Alberto Ferriani
May 11, 2005·Maturitas·P KenemansUNKNOWN International Tibolone Consensus Group
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Giulio FormosoEmilio Maestri
Dec 29, 2006·The Journal of Clinical Endocrinology and Metabolism·David F ArcherFrans A Helmond
Oct 28, 2006·Gynäkologisch-geburtshilfliche Rundschau·M Schmidt, R Kimmig
Mar 18, 2006·Arquivos brasileiros de endocrinologia e metabologia·Ana Karla M S O FreitasRui A Ferriani

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