PMID: 8979202Dec 1, 1996Paper

Endometrial biopsy in DUB

The Journal of Reproductive Medicine
S J AshG Flowerdew

Abstract

To determine the incidence of abnormal endometrial histology in women with dysfunctional uterine bleeding and to evaluate the predictive value of risk factors for endometrial cancer in women with dysfunctional uterine bleeding (DUB). We conducted a retrospective review of 310 women with DUB who underwent endometrial biopsy. The risk factors for abnormal endometrial histology included menstrual cycle irregularity, diabetes, nulliparity, hypertension, weight > or = 100 kg and age > or = 40 years. The incidence of endometrial abnormalities was determined, and the predictive value of combinations of risk factors was assessed using stepwise logistic regression. Twenty-one patients (6.7%) had abnormal endometrial biopsies. Menstrual cycle irregularity (P = .0001), age > or = 40 years (p = .022) and hypertension (P = .058) were independently significant risk factors for abnormal endometrial histology. The probability of abnormal endometrial histology in a premenopausal woman with DUB whose cycle was regular was < 1%. The presence of menstrual cycle irregularity increased the probability of abnormal endometrial histology to 14.3%. The patient who presents with DUB and a history of menstrual cycle irregularity warrants an endometrial bi...Continue Reading

Citations

Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·A Gervaise
Apr 18, 2002·The Journal of the American Association of Gynecologic Laparoscopists·George A VilosHelen C Ettler
Dec 21, 2013·The Permanente Journal·Malcolm G Munro, UNKNOWN Southern California Permanente Medical Group’s Abnormal Uterine Bleeding Working Group
Jan 16, 2007·Journal of Minimally Invasive Gynecology·Fawaz EdrisBasim Abu-Rafea

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