PMID: 9193892Jun 1, 1997Paper

Endometrial cancer and hormone replacement therapy. Appropriate use of progestins to oppose endogenous and exogenous estrogen

Endocrinology and Metabolism Clinics of North America
P J Sulak

Abstract

Most instances of endometrial cancer are potentially preventable. Unopposed endogenous estrogen stimulation of the endometrium has been shown to be the predisposing risk factor in most cases. Risk factors have been well-delineated, and it is important to recognize and treat the progesterone-deficient patient. Low-dose oral contraceptive pills in healthy, nonsmoking, older reproductive-aged women are an underutilized treatment modality. The many noncontraceptive benefits of longterm oral contraceptive use until the menopause should be explained to the patient, including the prevention of ovarian and endometrial cancer, the maintenance of bone density, and a reduction in the many surgical procedures performed for menstrual disorders. Progestin therapy in older reproductive-aged women and postmenopausal women with unopposed estrogen production is mandatory to prevent endometrial cancer. Knowledge and skill in simple endometrial sampling techniques performed in patients with known risk factors for endometrial cancer will often detect premalignant lesions that are treatable with progestin therapy or surgery.

References

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Citations

Mar 31, 2012·Frontiers of Medicine·Suchinda Malaivijitnond
Feb 28, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S RozenbergP C Lim
Apr 29, 2000·Journal of Clinical Epidemiology·M G JainG R Howe
Oct 26, 1999·Journal of Women's Health & Gender-based Medicine·D F BrophyJ M McKenney
Sep 13, 2003·The Journal of Cardiovascular Nursing·S Penckofer, D Schwertz
May 4, 2007·Menopause : the Journal of the North American Menopause Society·Arthur F Haney, Robert A Wild
Oct 16, 1999·Annals of Internal Medicine·S E McNagny
Nov 15, 2000·Journal of Psychosomatic Obstetrics and Gynaecology·C McVeigh
Sep 14, 2002·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A E Schindler
Oct 2, 2002·Obstetrics and Gynecology Clinics of North America·John A Collins, James J Schlesselman

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