Endometrial cancer in postmenopausal women using estradiol-progestin therapy

Obstetrics and Gynecology
Susanna JaakkolaOlavi Ylikorkala

Abstract

To estimate the risk of endometrial cancer in all Finnish postmenopausal women using various forms of estradiol-progestin therapy. All Finnish women (aged more than 50 years) who had used estradiol-progestin therapy in 1994-2006 for at least 6 months (n=224,015) were identified from the national medical Reimbursement Registry and linked to the Finnish Cancer Registry. A total of 1,364 type I and 38 type II endometrial cancers were recorded by the end of 2006. The incidence of endometrial cancer in estradiol-progestin therapy users was compared with that in the general population in this cohort study. The use of a continuous estradiol-progestin therapy regimen for 3 years or more was associated with a 76% reduction of the risk for type 1 cancer (95% confidence interval [CI] 6-60%). In contrast, the use of a sequential estradiol-progestin therapy regimen for at least 5 years was accompanied with a 69% elevation (95% CI 43-96%) if the progestin was added monthly, and with a significantly higher, 276% risk elevation (95% CI 190-379%) if progestin was added at 3-month intervals. Sequential regimens containing norethisterone acetate, medroxyprogesterone acetate or dydrogesterone administered orally showed no significant differences i...Continue Reading

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Citations

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Jul 11, 2014·American Journal of Epidemiology·Agnès FournierNathalie Chabbert-Buffet
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May 3, 2011·Gynecologic Oncology·Susanna JaakkolaOlavi Ylikorkala
Oct 2, 2021·Clinical Obstetrics and Gynecology·James H Liu
Jul 9, 2010·Current Opinion in Obstetrics & Gynecology

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